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Analysis of Retinal Functions

#A-644


Project for the Technology to Help Recording and Analysis of Retinal Function

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine
  • BIO-INF/Bioinformatics/Biotechnology
  • INS-OTH/Other/Instrumentation

Status
8 Project completed

Registration date
17.11.2000

Completion date
19.02.2008

Senior Project Manager
Melnikov V G

Leading Institute
MARTIG CO LTD University of International Economic Relations, Armenia, Yerevan

Collaborators

  • Nagoya University Shool of Medicine, Japan, Nagoya

Project summary

Since 1945 electroretonography plays special role as a method of functional analysis of eye diseases all over the world. Being sensitivity mean of the valuation of functional state of retina electroretinography provides the recognition of small biochemical violations causing clinical manifestations.

International Society for Clinical Electrophysiology of Vision (ISCEV) recommended the following main principia and standards to record electroretinogram (ERG) providing eye functions investigation of patients with optic system different violations:

– a response developed by the rods (in dark-adapted eye);


– a maximal response in the dark-adapted eye;
– oscillatory potentials;
– a response developed by the cones (in the light-adapted eye);
– responses to a rapidly repeated stimulus (flicker)

However, as mentioned in the report “Standard for clinical electroretnography (1998 Update)” approved by ISCEV “… there are also specialized types of ERG which may provide additional information about retinal function”. Moreover, there is a gap of the existence of recommended standards of local ERG recording (Govardovsky and oth. 1985; Shamshinova A. M. 1989; Sandberg M.A., 1977; Miyake Y., 1988, 1990; Biersdorf W.R., 1990). It’s known a method of local ERG recording developed in the laboratory of eye clinical physiology after S. V. Kravkov. The recorder is intended to provide the diagnostics of retina macular space local defeats.

Though, the use of color stimuli is known there is a flaw of developed tactic and methodology of the investigation. Moreover, there is a flaw of data related to local ERG responding to long stimuli.

The last progress in the area of clinical electroretinography is the method of multi-focal topographic investigation of optic tract bioelectrical activity (Sutter E.E. et al, 1985, 1986, 1992). This methods rises different arguments and didn’t get wide usage. The method allows to pursue topographic analysis of optic field and study nonlinear responses which are connected with optic tract adaptive mechanism.

Hence, investigations should be considered in present project are called to complete existing blank in this area, namely to use for:

– local electroretinography blue stimuli;


– multi-focal electroretinography the set of light emitted diodes (LED) providing retina irritation by color stimuli and long chromatic and achromatic stimuli;
– the development of mathematical model of retina functions by different channels and neurons localized in different layers. Thus, as a result the development of advanced method of multi-focal and local electroretinography;
– the study of new symptoms of cone and rod lesion.

Thus, summarizing above mentioned blank in electroretinogrphy we can formulate the following objectives of the project. The objectives of the project are to provide:

– the development of methods of retina irritation by blue stimuli (local electroretinography);


– the development of methods of multi-focal electroretinography. The method is based on the use of light emitted diodes (LED) set providing retina irritation by color stimuli and long chromatic and achromatic stimuli;
– the development of the computer based technology providing the measurement the signal as a response of retina irritation by both color stimuli and long achromatic and chromatic stimuli;
– the development of the mathematical model of retina functions for different channels and neurons localized in different layers;
– the investigation of symptoms of cone and rod defeats;
– the development of methods of ERS component image recognition and spectral analysis.

The impact of the research should provide the development of computer based measurement means for the progress in the field of electroretinography. Existence of computer unit should provide programmable change and selection of the regime and types of retina light irritation and realize the solution of the following problems for clinical electroretinography:

– irritation of retina by blue stimuli;


– irritation of retina by the set of LED;
– retina irritation by both color stimuli and long achromatic and chromatic stimuli;
– mathematical modeling of retina functions for different channels and neurons localized in different layers;
– the study of the state of retina on the results of the investigation of symptoms of cone and rod defeats;
– ERG component image recognition and spectral analysis.

As we can conclude the project is multidisciplinary and hence it involves in the team specialists in Electrophysiology, Mathematics, Programming, Electrical Engineering and Computer Sciences. Therefore, specialists are distributed in accordance with there activity:

Team #1. Team of Mathematicians and Computer Scientists (Programmists, Electrical Engineers). This team involves Prof., Dr. Aram H. Arakelyan, Kandidate of Sciences Karen Z. Hairapetyan, Kandidate of Sciences Levon A. Manukyan, Hrair R. Avetisyan, Hayk V Isakhanyan, Pyotr Alpetyan, Henrik Aghinyan, Svetlana Yakhshibekyan. The leader of the team Aram H. Arakelyan is a specialist in Computer Sciences and Applied Mathematics. He has works in biomedical signals treatment, image recognition and spectral analysis. He is an author of the Monograph in Optimization of Dialogue Information Systems, Monitoring of Forest Landscapes and Relational Data Bases and participated in the development of computer based cardiological systems of intensive care.

Team #2. Team of Electrophysiologists involves Prof., Dr. Angelika M. Shamshinova, Kandidate of Medical Sciences Orlovskaya Liudmila Savishna, Kandidate of Medical Sciences Marine Airiants, Doctor Eskina Erika Naumovna, Doctor Krivosheev Anatoli Anatolievich. They have researches in the area of Clinical electroretinography. Especially, Prof., Dr. Angelica M. Shamshinova is internationally recognized specialist in Electrophysiology, Member of ISCEV, author of monograph in Functional methods of investigations in ophthalmology.

Team #3. Team of Electronics Engineers. This team involves Dipl. Engineer Haroutyunyn Khachik and Dipl. Engineer Avetisyan Karlen. They are experienced specialists in the development of the equipment for antimissile defense control. It’s expected to involve these specialists to solve the following tasks:

– development of computer aided means and production of the equipment units for ERG functional analyzer;


– testing and debugging of ERG functional analyzer.

It’s expected to develop computer based means providing functional analysis and mathematical modeling of retina functional state (bioelectrical activity and functions of optic system different channels). The developed ERG functional analyzer should provide to:

– recompense expenses made during its development;


– initiate production of medical analyzer chipper than existing prototypes;
– a number of scientific problems related to the development of methods of multi-focal and local electroretinography and mathematical modeling of retina functions should be solved.

The project addresses to ISTC following objectives:

– disorientation of high personal staff to solve peaceful problems;


– support of fundamental and applied research to produce medical means;
– further integration of scientists from military area into world scientific community;
– will be solved the recommendation of ISCEV to promote the research in clinical electroretinography to learn about and to maximize the diagnostic value of ERG;
– will be recovered a collaboration between Armenian and Russian scientists and expanded there collaboration with scientists from advanced Western countries.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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