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Surveillance of Measles in Russia

#3815


Development of Laboratory Surveillance Capabilities for Measles in the Russian Federation

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine
  • MED-DIS/Disease Surveillance/Medicine

Status
3 Approved without Funding

Registration date
03.09.2007

Leading Institute
Gabrichevsky Institute of Epidemiology and Microbiology, Russia, Moscow

Supporting institutes

  • State Research Center for Applied Microbiology and Biotechnology, Russia, Moscow reg., Obolensk

Collaborators

  • Centers for Disease Control and Prevention (CDC) / Measles, Mumps Rubella and Herpesvirus Branch, USA, GA, Atlanta

Project summary

Measles outbreaks continue to occur in the Russian Federation. The spread of the disease can be limited with early identification of outbreaks and sporadic cases and vaccination of all susceptible contacts. Timely and efficient detection of measles infections requires that reliable standardized diagnostic tools are available and that these tests are performed correctly and in a timely manner.

Absence of standardized, easy to use, inexpensive locally produced diagnostic tests could become a major obstacle to successful implementation of sustainable measles control program. While public health institutions in the Russian Federation could temporarily rely upon relatively expensive imported IgM and IgG test kits that are provided by the international organizations in limited quantities, there is an immediate demand for locally produced assay kits that should be consistent with WHO standards. It will be very difficult to expand laboratory surveillance if the labs must purchase assays kits from foreign countries. Suitable expansion of laboratory surveillance will relay on the availability of inexpensive, locally produced kits. The overall goal of the proposed project will be to enhance laboratory surveillance capabilities for measles in the Russian Federation. Specifically the project will focus on development of sensitive and specific diagnostic assays for use in the Russian Federation. These assays will be locally produced under GMP conditions and validated according to the established WHO criteria. The proposed project would provide weapons scientists that had been engaged in bioweapons development new opportunities to participate in an international public health partnership. The project would significantly increase innovation in public health laboratory science by having experienced biomedical scientists focus on applied research in developing diagnostics for measles. The research results could be extended to other laboratories within the WHO Labnet.

The project will culminate in working out a package of protocols, regulating the procedures of production, quality control and application of ELISA diagnostic kits which are to be developed for measles diagnosis.


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