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Information System for Tumours Centre

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The Experimental Chemotherapy of Tumours Information System of Cancer Research Centre RAMS

Tech Area / Field

  • INF-DAT/Data Storage and Peripherals/Information and Communications
  • MED-DRG/Drug Discovery/Medicine
  • BIO-INF/Bioinformatics/Biotechnology

Status
8 Project completed

Registration date
14.09.1998

Completion date
27.05.2003

Senior Project Manager
Bugaev D V

Leading Institute
NIIIT (Pulse Techniques), Russia, Moscow

Supporting institutes

  • Cancer Research Center, Russia, Moscow

Collaborators

  • US Department of Health & Human Services / National Institute of Health / National Cancer Institute, USA, MD, Bethesda

Project summary

The Purpose of the Project is to develop an information system on experimental chemotherapy of tumors combining functions of reference Databank and expert system to be available via INTERNET for foreign and Russian researchers in antitumor chemotherapy and research and development of new drugs.

N.N.Blokhin Cancer Research Center has begun to develop a Databank of antitumor agents. The Databank is intended to provide relevant chemical and biological information for investigators doing research in new biologically active substances and analytic study in experimental chemotherapy of tumors, in particular as concerns ‘structure-activity’ relationship to predict potential effects of substances, availability of antitumor agents from various natural objects, strategy of search for new antitumor agents.

Information contained in the Databank is taken from published and mainly unpublished reports on 10,000 synthetic substances and natural products that have been tested for potential antitumor activity at the Center laboratories since 1952. We performed detailed analysis of the application domain “Experimental chemotherapy of cancer” and developed a Databank conceptual model and data structure. Next to half of the information was formalized and presented as computer databases. The databases are operated with IBM PC. The database of structural chemical formulas and some chemical characteristics has the .db format and is operated by ChemBase systems. The databases on drug properties are maintained in the .dbf format and operated by FoxPro and Excel systems.

One of the Project objectives is to solve technical and programming problems to accomplish the Databank development such as computer up-dating, creating a local computer network, arranging Databank availability via INTERNET, adapting existing programs for Databank tasks.

The another objective is to formalize and input to computer whole available information on antitumor agents studied in N.N.Blokhin Cancer Research Center, to edit all databases, to translate the databases in English.

As a result, the Russian and foreign specialists in searching and development of new antitumor drugs will obtain the information system containing original data and additional to informational resources available at present.

The information system is intended for biologists, chemists, pharmacologists and medical workers. The estimated number of the information system potential users is several thousand.

Potential role of foreign participants

The heads and leading specialists of the Project have scientific and business interactions with specialists from interested foreign institutions doing research in cancer genesis and diagnostics as well as in antitumor chemotherapy and development of new drugs:

· European organization for researches in treatment of cancer (EORTC), Department NDDR (New Drugs Developments Researches), Brussels, ES;

· ROSWELL PARK Cancer Institute, GRACE Cancer Drug Center, Buffalo, New York, USA;

· National Cancer Institute USA, Bethesda, Meryland, USA;

· RHONE-POULENC RORER, Central Research, Paris, France;

· ISKRA INDUSTRY CO., LTD, Tokyo, Japan.

The Project workers are also interested in contacts with all other foreign organizations wich will promote successful progress of the Project (MDL Information Systems, Inc.; Microsoft; INTEL a.o.).


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