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EMF Sedative Cellular Mechanisms

#A-368


Cellular and Molecular Mechanisms of Pain Releasing Effect of Electromagnetic Fields

Tech Area / Field

  • MED-OTH/Other/Medicine
  • BIO-RAD/Radiobiology/Biotechnology

Status
3 Approved without Funding

Registration date
01.07.1999

Leading Institute
National Academy of Sciences of the Republic of Armenia / Biophysics Center, Armenia, Yerevan

Project summary

According to the theory of Krighanovsky (1993), pain is the hyperactivation of pain sensitive neurons of the central nervous system which forms pathologically increased pain generation center. According to our hypothesis (Ayrapetyan, 1997) cellular pain excitability is based on the hyperhydration of nerve cells. Previously it was shown that in cell membrane protein molecules defining excitability, chemosensitivity and enzymatic properties of the membrane are in active and inactive (reserval) state, and their correlation is regularly changed depending on cell hydration degree.

Cell swelling leads to the increase of excitability, chemosensitivity, and other activities. Dehydration has an opposite effect. It was also shown that cell excitability as well as any other inhibition of metabolic activity leads to its hydration. Thus the positive feedback is formed between excitation and hydration. On the basis of these data a hypothesis on pain (nociceptive) signal generation was suggested according to which cell hyperexcitation is the result of its hyperhydration. From this hypothesis it could be suggested that factors leading to dehydration can have antinociceptive effects.

Previously it was shown that Na-K pump is one of the main regulators of cell volume. Its inactivation leads to the increase of cell hydration whereas the activation - to its dehydration.

It was also suggested that the biological effect of magnetic fields (MF) is realized through changes in water medium of the cell (Piccardi 1967, Ayrapetyan 1986, Grigorian 1995, Gharibova 1996). It was shown that cells in hydration state are more sensitive to MF (Danielian 1998). As in hydration state MF causes dehydration of cells through the activation of Na-K pump, it is suggested that MF could be used as a pain releasing factor.

Modulation of electromagnetic waves (EMW) is used in the basis of modern weapons production. These waves can cause psychoneurological disorders in humans. Previously within the framework of the military program “Mnenie” (in former Soviet Union) the Biophysics Center has participated in the elaboration of cellular - molecular mechanisms of the effect of ionizing radiation and EMW on the organism. The aim of these investigations is to increase the effectiveness of these factors as well as work out new means of protection.

The current project opens new prospects for further experimental and clinical studies of molecular mechanisms of pain releasing treating effect of EMF on the organism in the presence of pain syndromes at various etiologies.


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