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Bcteriophages against Chronic Prostatitis Microflora

#G-1369


Microflora of Inflammatory Process in Chronic Prostatitis and Urogenital Tracts in Men and Phage Therapy Prospects

Tech Area / Field

  • MED-OTH/Other/Medicine
  • BIO-CHM/Biochemistry/Biotechnology
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology

Status
8 Project completed

Registration date
23.11.2005

Completion date
26.01.2010

Senior Project Manager
Weaver L M

Leading Institute
Georgian Academy of Sciences / Institute of Bacteriophage, Microbiology and Virology, Georgia, Tbilisi

Collaborators

  • Southwest Regional Wound Care Center, USA, TX, Lubbock\nProstatitis Foundation, USA, IL, Smithshire

Project summary

The objectives of this project are as follows:
  • To isolate pathogenic bacteria during chronic prostatitis and urogenital diseases.
  • To develop phage preparation which will prevent or substantially reduce the damage caused by chronic prostatitis and urogenital diseases on the base of the above mentioned knowledge.
  • To carry out small-scale controlled comparative clinical trails by using phages and antibiotics each of them separately and their jointly application.

Today, because of a high rate of morbidity, lethality and considerable social-economic damages, purulent-inflammatory infections still remain an actual problem of the World Health. Problem of serious injuries and complications caused by urological interventions is still an actual despite the improvement of surgical techniques, application of new antibiotics and chemotherapeutic remedies. In the development of infectious complications great attention must be paid to the evaluation of a role of the microbial factors, as species of microbes causing infection determine the seriousness of the disease current and specificity of morphological changes in organs. Prostatitis plays an important role in urologic pathology of men and attracts the attention of urologists, venerologists, reproductors and sexual pathologists. In recent years a sharp increase of inflammatory disease of prostatic glands was observed. Etiological structure of prostatis is rather compound and perse. Significant changes occurred under the effect of intense selective action of antibacterial preparations in particular, antibiotics. Acquired antibiotic-resistance is one of the significant problems of the recent medicine throughout the world and Georgia is not exception that’s why searching of new alternative methods of treatment acquires a particular significance. Phage therapy after the emergence of antibiotics in US and West Europe largely disappeared from view and in fact few researches on phages were carried out. However, phage therapy was ongoing in East Europe, particularly in Poland and former Soviet Union. More intensive investigations on the production and utilization of therapeutic phages for the prevention of infectious disease were carried out in Tbilisi, Georgia. Laboratory of Morphology and Biology of phages at the G.Eliava institute of Bacteriophages, Microbiology and Virology, Georgian Academy of Sciences has been researching basic issues of bacteriophage and creation of phage preparation for many years and it has gathered a wide experience, the group of researchers performing this project has worked on severe infectious diseases for many years. Present project will allow then to use their scientific potential in the work for peace, more exactly in medicine against urogenital pathology. At the same time it must be remarked, that interest in phage related issues and phage therapy significantly increased in US and West Europe during the last years, because of multi-resistance of strains towards the widely used antibiotics. This is proved by the fact that research groups and companies are being established in order to carry out the on bacteriophages. Physicians are powerless in the struggle against antibiotic resistant strains. Collaboration with these groups will be useful and it will support the process of integration between scientists and physicians of different countries.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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