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Carcinogenic Compounds and Plant Reproduction


The Influence of Carcinogenic Compounds and their Metabolites on Plant Reproduction

Tech Area / Field

  • AGR-FOD/Food & Nutrition/Agriculture
  • BIO-CHM/Biochemistry/Biotechnology

3 Approved without Funding

Registration date

Leading Institute
Durmishidze Institute of Biochemistry and Biotechnology, Georgia, Tbilisi

Supporting institutes

  • Ketskoveli Institute of Botany, Georgia, Tbilisi


  • Charles H. Babcock Chair in Botany, USA, Winston-Salem\nInstitute of Systematic Botany & Plant Research Laboratory, USA, New York\nUniversity of Colorado / E.P.O. Biolody Department, USA, CO, Boulder

Project summary

The proposal seeks to investigate metabolism of carcinogenic compounds (polycyclic aromatic hydrocarbons – PAH) in plants and to study the impact of PAH and their metabolic products on seed development. Experimentally will be determined how different plant species tolerate to PAH expressed in the success of sexual reproduction of plants growing in polluted environment. Special attention will be paid to investigate the tendency of PAH accumulation within the seed and fruit tissues of higher plants. Preferably will be analyzed seed and fruit tissues of plants, so as accumulation of PAH and their derivatives in reproductive organs might influence on the destiny of the next generations. Determination of PAH accumulation in different plants growing on contaminated pastures, which are grazed by domestic stock, will be represent potential danger for human health.

In general, three questions will be studied:

1. To determine metabolism pathways of PAH in natural environment.

2. To study impact of PAH and their derivatives on seed and fruit production in higher plants and on seed quality and to determine the survival tendency of separate plant species in contaminated environment.

3. To determine plant species, which can transform PAH during metabolic pathways and, therefore, represent importance for maintenance of human health affected by pollutants via food chain.

Determination of biotransformation pathways of carcinogenic compounds into the plant cell and investigation of their influence on sexual reproduction of plants will be highly significant for understanding of impacts of PAH and their derivatives on biopersity in plant communities, as well as for protection of human health due to exclusion of these products from food chain.


The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.


ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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