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Physics Methods for Eye Pathology Diagnostics

#1717


New Methods of Early Diagnostics of Some Forms of Eye Dystrophic Pathologies

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine
  • BIO-CHM/Biochemistry/Biotechnology

Status
3 Approved without Funding

Registration date
16.12.1999

Leading Institute
VNIIEF, Russia, N. Novgorod reg., Sarov

Supporting institutes

  • MNTK "Eye Microsurgery", Russia, Moscow\nNational Nuclear Center of the Republic of Kazakstan / Institute of Nuclear Physics, Kazakstan, Almaty

Project summary

Differential diagnostics of eye diseases at their initial stages is a very complicated problem, thereby new analysis techniques development is actual. Early diagnostics and well-timed treatment give an opportunity of saving an eye as a functional organ.

Special investigations show that various pathological states of the vision organ cause different changes in a tear liquid composition. This fact provides additional opportunities for eye diseases diagnostics. It has been found that such widespread diseases as cataract, glaucoma, tubercular eyes lesion, myopia are accompanied with definite by orientation quantitative changes in concentrations of some microelements (ME).

According to the above, the study of ME content in media and blood of men with different forms of eye dystrophic pathology gains particular significance.

Nowadays the development of a new direction of laboratory diagnostics – clinical crystallography, which involves study of structure formation in biological liquids – is of interest. It becomes of particular importance being applied to diagnostics of initial stages of various diseases, including eyes ones. By present there have been developed new methodical approaches and criteria of estimation of the bio-liquid crystallographic picture, which is formed in the process of its self-organization at the “liquid – solid” phase transition. However, for eye pathologies these studies are generally carried out with the method of polarization-optical crystallography in the closed optical cell. For early diagnostics purposes the method of self-organization (method of the native bio-liquid crystallization in an open drop) being combined with chemical analysis of glass bio-liquid composition is of great interest.

There exist certain methodical difficulties with “track substances” definition, which are due to low concentration of investigated elements as well as to impurities, which can appear on the objects under study as a result of their contact with the environment, reagents and instruments during samples preparation. Taking into account physiological importance of microelements in the human body (microelement homeostasis) and discovered tendencies in their distribution over the bio-liquid structure as a “norm” and a “pathology”, the use of the following methods for analysis of the bio-liquid structures element composition is considered to be of promise in diagnostics: the X-ray fluorescent method, which allows finding negligible quantities of substance in a sample under study, and the proton probe method, which provides acquisition of information about element composition from the sample areas of micron dimensions, and also allows gaining the maps of the elements distribution in a sample. The use of these methods will provide essential widening of diagnostic potentialities of the bio-liquid crystallization technique.

The present project is in full accord with the ISTC objectives:


· this is a new development offering promise for being used with peaceful purposes primarily in medicine, ecology;
· the present project outcome is in conformity with civil needs;
· it encourages involving the Russia weapons scientists and engineers into the international scientific community.

The Foreign partners Role:


· Potential partnership in results commercialisation.
· Information exchange during project implementation.
· Mutual review of technical reports.
· Joint seminars, workshops, meetings, consultations.
· Consultation on intellectual Property Rights, in case of joint invention.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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