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X-Ray Microradiography for Bioobjects

#3462


Prototyping of the Nanosecond Micro-Radiography Technique for the Bio-Objects Testing in Active Condition to Study Radiation Resistance and to Compare This Method Self-Descriptiveness with Scanning Probe Microscopy

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology
  • ENV-MRA/Modelling and Risk Assessment/Environment
  • FIR-NSS/Nuclear Safety and Safeguarding/Fission Reactors
  • FUS-MCS/Magnetic Confinement Systems/Fusion

Status
3 Approved without Funding

Registration date
20.02.2006

Leading Institute
ITEF (ITEP), Russia, Moscow

Supporting institutes

  • VNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Lawrence Livermore National Laboratory, USA, CA, Livermore\nInstitute of Plasma Physics & Laser Microfusion / International Centre for Dense Magnetised Plasma, Poland, Warsaw

Project summary

It is proposed to provide theoretical and experimental investigations on the creation and testing of pulsed nanosecond X-ray micro-radiography of bio-objects in a course of their vital functions. Scientific facilities created on the base of plasma focus and laser produced plasma devices will give a possibility of visualization of biological objects with micron spatial resolution.

To the present moment the excellent apparatus for nanometer microscopy was made, which has been based on electron and micro-probe (tunnel and atomic-force) microscopes. In the majority of the cases these devices exploit special methods of preparation and immobilization of objects (concentration, drying, attaching to a substrate, metallization, etc.), which can distort the object under investigation and in any case do not allow counting these objects live. And what’s more these techniques permit investigating mainly the surface of an object.

In our Project the methods of the transmission X-Ray radiography with the phase contrast of an image will be used. This phase contrast will be distinguished by several different approaches in both stages – X-ray radiography and visualization. It will give a possibility to provide information on internal structures of a biological object and to increase quality of the X-Ray images with simultaneous decrease of a dose load on them. At the same time due to short nanosecond pulses the image of an object will be taken in the regime of its inertial confinement (i.e. the time of its evaporation under the action of the visualizing radiation will be long compared with the exposure time). It will allow taking an image of microstructures before production deformations of them by the irradiation, thus increasing the precision of the radiography measurements. It is important also, that the repetition rate of the transmission X-Ray pulses may be provided on the level of 0.05 through 10 pps. It will allow investigation of various processes dynamics in different microscopic biological and other events.

In parallel to the technique of micro X-ray radiography development the objects will be studied by the method of electronics and micro-probes. All these researches will be provided with the aim of investigation of the radiation resistance of the bio-objects with the regard for soft X-ray radiation power (not only dosage) and for the comparison of self-descriptiveness of the method with the scanning probe microscopy.

As a result of the Project fulfillment a laboratory model of the system prototype of the soft X-ray micro-radiography of bio-objects in a course of their vital functioning will be created.

Specialists, engaged before in various types of nuclear weapon development, production of related materials and tests of special military technique, will be involved in the Project.

Meeting ISTC Goals and Objectives: as a result of the activity on the Project the re-orientation of the scientists and specialists into civil investigations engaged before in creation and test of weapon will be realized.

Role of foreign collaborators within the Project – mutual discussions and corrections of plans, intermediate and final results of the works, joint operations and investigations, participation in methods developments, organization of seminars, assistance in marketing, possible subsequent mutual use of the technology and prototypes elaborated (e.g. application of the achievements of science to production, etc.).


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