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Natural Biopreparations from Georgian Plants


Paramedicative Preparations: 1. "Ushkhuni"; 2. "Shindis julabi"; 3. "Antslika" (Extracts of Tkemali, Dogwood, Elder) and 4. "Kurtkheuli" – Immunomodulators and Protectors from Ecologically Pure Natural Plant Resources of Georgia. Standardization, Study, a

Tech Area / Field

  • MED-DRG/Drug Discovery/Medicine
  • BIO-CHM/Biochemistry/Biotechnology

3 Approved without Funding

Registration date

Leading Institute
Ikato Ltd., Georgia, Tbilisi


  • University of Turku / Finnish-Russian Joint Biotechnology Laboratory, Finland, Turku\nNational Institute of Advance Industrial Science and Technology, Japan, Tsukuba

Project summary

In Georgia medicative means of natural origin have been in intensive use from ancient times. Their properties have been described in medical books. At the current stage of scientific development, intensive research is conducted to seek and create new synthetic preparations. About two thirds of healing means used in medicine are of synthetic origin. They achieve healing effects in treatment quickly, but the human organism is less adapted to them and, in addition to pharmacological efficiency, they also demonstrate serious toxic effects. In most cases, these various side effects are more dangerous than the diseases themselves. Drug-caused diseases are a reality of our time. That is why we must rationally use everything that Nature gives us. An urgent current problem is the use of natural compounds with immuno-therapeutic effects for healing purposes (health preservation and curing).
Georgian researchers, including project participants, have been conducting productive work to create and study natural preparations; in this respect particularly intensive activity was shown by the company Ikato Ltd., founded in 1993. At present the company owns several preparations, including Ushkhuni, Shindis julabi, Antslika and Kurtkheuli. The first three preparations are registered, and they are already popular and acknowledged in scientific circles. However, owing to financial difficulties, Ikato Ltd. does not produce them. The fourth preparation, Kurtkheuli, is an absolutely new, unregistered preparation, the composition of which is not yet known.
The purpose of the present project: to create a scientific-methodological basis for further work on the above-mentioned natural preparations, to improve the technology of their production, to extend the study of their chemical composition and healing effects by use of paraclinical and clinical methods, to extend the range of their application, and to attract, where possible, the interest of scientists from developed countries in research and appraisal work.
1. Preparation of raw materials and other material and technical supplies. a) raw material: plants and parts of plants, collected from ecologically clean places; b) required materials, consumables, maintenance materials and other supplies;
2. Standardization of raw materials, intermediate and end products: a) the study of chemical composition (vitamins, organic acids, alkaloids, glycosides, phlavanoids, amino acids, steroids, antioxidants, anthocyans, phitoncides, electrolytes; b) investigation of ecological purity (radioactivity, herbicides, lead, aluminum, tin); c) investigation of microbiological purity (fungi, parasites, sweatogenic microbes).
3. Perfection of the technology. The selection for each preparation of more rational and appropriate production forms (powder, tablets, fizzy tablets, extracts, syrups);
4. Out-patient and clinical appraisal of research results, including: a) working upon the methods of treatment and prevention of atrophic gastritis with secretory insufficiency of different degrees; b) study of the effects of the developed preparations on the microflora of the stomach to prevent cancerous transformation of the latter; c) study of the role and importance of the immunomodulatory effects of the proposed preparations.
5. Making application for the registration of intellectual property of international importance
6. Presentation, together with collaborators, of the preparations at international exhibitions; market research for future commercialization, together with the ISTC or another potential partner.
Expected Results and their Application
The project falls into the category of applied research, the results of which will be as follows: the connections with scientists, among them foreign ones, doing research in similar and adjacent fields will be established; several foreign organizations will become acquainted with the proposed preparations; the range of applications of these preparations will be extended; timely treatment of chronic gastritis accompanied with low acidity will prevent many complications in patients; revealed immunomodulatory effects of these preparations of plant origin will be used to avoid many undesirable complications; free treatment and free distribution of preparations will increase the number of patients under observation; upon project completion the development stage will follow, preferably with foreign partners.
The field of application is very wide: immunology, gastroenterology, oncology, diabetology, urology, laryngology, cardiology, and hematology.
The Importance of the Project
Project implementation will enable the wide introduction in clinical practice of highly efficient paramedical preparations, the harmlessness of which has been proved and established very well by Georgia's traditional medicine.
Technical Approach and Methodology
For the preparation of the drugs the following methods will be used: drying, grinding, tincturing, extracting, evaporation, condensation, homogenization, pasteurization, and sterilization.
Physical methods (alcoholometry, density measurement), chemical methods (alkalimetry, acidimetry) and physico-chemical methods (refractometry; photometry; spectroscopy; spectrophotometry; polarimetry; potentiometry; paper, sorbite thin layer, ion-exchange, gaseous and gas-liquid chromatography) will be used for the study of the chemical composition of raw materials and end products, and for the compilation of technical normative documentation.
Clinical and paraclinical methods will be used in the research (X-rays, endoscopy, intragastric pH-metry, determination of "T" and "B" lymphocytes and helpers, ultrasonography, micromorphological study of the biopsy of mucous membrane of stomach and intestines). The pathogenic mechanisms of some diseases will be studied, and the role and importance of the proposed preparations in prevention and treatment of different diseases will be determined.
The parameters of cellular and homoral immunity will be clarified and the subpopulation of lymphocytes will be determined by immunophluorescent assay using monoclonal antibodies. Determination of immunoglobulines of the GAM classes will be achieved by the Manchini radial immunodiffusion method and the total level of immunoglobulin E in the blood serum will be ascertained using ELISA.
The urgency of the above problems consists in the fact that at present, in light of the worldwide interest in medical preparations obtained from natural resources, the designers of the present project propose unique and efficient paramedical preparations produced from ecologically pure plant resources of Georgia. The team of project scientists has long tradition of working with these problems and they have produced many editions, monographs, publications, textbooks, etc. The Project participants have plans for future implementation, connected with the Project subject, which are even more bold.
Meeting ISTC Goals and Objectives
The project will enable experts, previously engaged at military institutions, to use their qualifications, knowledge and experience, for the following: protection of public health; protection of the environment; the use of the gifts of the Nature; maintaining links with the international scientific community, with collaborators; participation in various symposia, conferences and exhibitions; issuing publications; supporting the transition to a market economy and responding to civil needs.
In January 2000 the newspaper "Pharmaceutical Bulletin - Media", published a report made at the conference "Medicine and Religion", held on December 15, 1999 at the offices of the Orthodox Patriarch of all Georgia. Spokeswoman Mrs. Nana Manjgaladze was awarded an Honorary Diploma of the Holy and Blessed Ilia the 2nd, Cathalicos-Patriarch of all Georgia, - "For her efforts in the development of medicine in Georgia and for unselfish service to the people".
In 1997-1999, at the international exhibition of medical drugs in Tbilisi, the three above-mentioned preparations of the company "Ikato Ltd" were presented. No other drug from other countries could compete with them in respect of their originality and uniqueness.
Well-known Georgian scientists are participating in this project, to ensure that these preparations attain their well-deserved recognition and promotion.


The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.


ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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