Medical Effects of Radioactive Elements Mining
Assessment of Population’s Health Risk and Ecomedical Security in the Region of Technogeneous Anomaly in the Kyrgyz Republic
Tech Area / Field
- ENV-EHS/Environmental Health and Safety/Environment
- ENV-MRA/Modelling and Risk Assessment/Environment
- ENV-WPC/Water Pollution and Control/Environment
3 Approved without Funding
National Surgical Center, Kyrgyzstan, Bishkek
- Scientific and Production Center for Preventive Medicine, Kyrgyzstan, Bishkek
- Medical Research Council / Immunochemistry Unit, UK, Oxford\n[Individual specialist]\nFriedrich-Schiller-Universitat / Institute of Human Genetics and Anthropology, Germany, Jena
Project summaryThe Project objective: Setting up biomorphotest of placenta for assessment of radio–ecological burden impact on pregnant women’s health, development of fetus and baby living in the area of Mailusuu technogeneous anomaly.
The Project is targeted at the decision of urgent issues of applied ecobiomedicine:
- characterize raised radio–ecological burden on human organism in the area of Mailusuu technogeneous anomaly;
- raise efficiency of actions on timely detection and assessment of adverse ecological and biomedical impact on human organism;
- undertake up-to-date and comprehensive measures on prophylaxis and treatment of pregnant women, fetus and baby.
The Project backbone: During the Project implementation, the radio–ecological situation in the area of Mailusuu technogeneous anomaly and its impact on the area population’s health will be assessed. The outcomes of morphological research of a pregnant woman’s placenta will enable to develop placenta biomorphotest for efficient protesting and forecasting ecobiomedical consequences of higher radio ecological background.
The Project urgency is explained by the existence of more than 37 tailing dumps in Kyrgyzstan without duly control. Only in one of such regions – Mailusuu city and its outskirts there are 24 tailing dumps and 15 mountainous terrace where one can notice:
- increased radiation background (2.5-2.8 times higher than maximum permissible concentration (MPC);
- increased content of heavy metal salt in soil and water of Mailusuu river (several times higher than MPC). There is high probability of tailing dump destroy as a result of natural disasters (earthquake, landslide, avalanching, etc.) that can lead to radio–ecological pollution of not only adjacent territory but also transboundary infection.
In these conditions, the most vulnerable residents of Mailusuu technogeneous area are the pregnant women. Perspective object for judging reproductive health condition, as well as peculiarities of perinatal pathology in these conditions is a placenta, which is highly informative, provisional organ, which determines and characterizes further biological formation of a newborn child. It should be noted that researching technology of the existing biological tests–prototypes such as salmonellas/microsomes is difficult, less accessible, requires well–prepared specialists, whereas placenta survey on the basis of any city or rayon health care facility is accessible and effective.
The project participants suggest along with the collaborators conducting histomorphometric research of parturient women’s placenta – the residents of the present region. On the basis of the conducted research the criteria on assessment of histomorphometric indicators of radio ecological burden impact on parturient women’s placenta and biomorphotest on forecasting ecobiomedical consequences of raised radio ecological burden will be developed. Development of biomorphotest of parturient women’s placenta will be a unique method of biotesting environment ecological burden that enables to use this method widely and efficiently in ecobiomedical practice. The Project rests on scientific research expertise, the specialists’ participation in the international projects, and their research work (see Paragraph 12 – Supporting Information). Studying the issues on radio biogeochemical burden on pregnant women’s organism in the conditions of raised radiation background and altitudinal belts, the research was conducted in this field. The research was based on the work of international scientists: E. P. kalashnikov 1986, A. P. Milovanov, 1999, M. V. Fedorov 1986, A. I. Brusilovski 1976, V. I. Bodiazina 1986, S. C. Town, J. L. Patterson, C. Z. Pereira 2004, P.F. Flood, N. J. Tyler 2004, McKehha, Daniel 2005, Ushizawa, Koichi, Kaneyama Kanako 2004.
Project Category – “Applied Research” cumulated during ecobiomedical research, development of medical technique and different control means and achievements including experience of “weapon” scientists in the sphere of radio biochemical protection, joint integrated research with the various institutes of Europe and CIS countries: the faculty of the International State University named after Lomonosov (Russia), National University of Ireland, Department of HORTECO (Belgium), Lausanne University, the Institute of Mineralogy and Geochemistry (Switzerland), Department of Water and Environment of Paster Institute (France), Research Center of Hygiene and Epidemiology (Kazakhstan), Water Problem Institute of AS (Uzbekistan), SRI of Medicine, Labor of the RAMS with Finnish Environment Institute (Helsinki), Alex Stewart Company, Caspian Central Asian Foundation (Canada), National Health Institute of the USA, Texas University (USA) with the participation of international scientific associations (CPR). The outcomes of participatory research were reported at scientific conferences: symposiums with international participation “Ecology and Surgical Pathology” (Bokonbaevo, 204), “Regional Pathology” (Cholpon–Ata, 2005), “Ecobiomedicine of Issyk–Kul” (Jetioguz, 2006)and were published in periodicals. Proper resolutions on the outcomes were adopted with the participation of international scientific associations It is necessary to point out that technogeneous reason in our focus area – Mailusuu technogeneous anomaly – is, first, “weapon” problem, since it relates to wrong utilization of uranium wastes.
The following main tasks are solved for the project objective implementation:
- determine basic radioecologial situation in the area of Mailusuu technogeneous anomaly;
- survey impact of raised radioecological burden on the condition of reproductive health of the women, fetus and baby living in the area of Mailusuu technogeneous anomaly;
- assess possibility of using partiturient woman’s placenta as biomorphotest on forecasting ecobiomedical consequences of raised readioecological background.
The main outcomes received on the Project implementation will be:
- comprehensive ecobiomedical characteristics of Mailusuu technogeneous anomaly with the assessment of impact of the main negative factors on human organism (on the example of a pregnant woman, developing fetus and new–born child);
- sample of accessible effective biomorphotest–placenta of a parturient woman who lives in ecobiomedical adverse places;
- closing report on medical tests and preparation of conditions for application of this methodology in ecobiomedical practice.
It is expected that the received outcomes:
- may expand the potentials of ecobiomedical specialists, simplify technology of biotesting environment condition in adverse area:
- will be the basis for arranging thorough monitoring of environment in the area of man–caused anomaly;
- will have international capacity and may become the basis of long–term interaction of ecobiomedical specialists with all the stakeholders;
- will enable to continue work on improving a system of environment biotesting and ecobiomedical technology in the present target.
The Potential Role of Foreign Collaborators:
- information exchange during the Project implementation;
- participation in technical testing of the Project activity,
- conduction of participatory symposiums and workshops;
- practical application of the outcomes and partnership in their commercialization;
- technical participation in the decision of the Project tasks;
- setting up of joint technologies on environment biotesting.
On developing parturient women’s biomorphotest–placenta the requirements of international and Kyrgyz standards including medical ones will be taken into account. It is planned to patent development of biotests that will enable to use biotest on beneficial terms more actively on various ecologically adverse sites. First, the development is planned to be tested in a basic unit, and then the project participants and health care facilities from the republic and abroad can be involved in a practice.
The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.
ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.