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Hepatitis B Virus Subtypes

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Evaluation of the Prevalence of Hepatitis B Virus Subtypes within the Russian Federation

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • MED-DIS/Disease Surveillance/Medicine

Status
3 Approved without Funding

Registration date
31.03.2000

Leading Institute
State Research Center of Virology and Biotechnology VECTOR, Russia, Novosibirsk reg., Koltsovo

Project summary

Title of the Project: Evaluation of the prevalence of hepatitis B virus subtypes within the Russian Federation.

The goal of the Project is to study the prevalences of hepatitis B virus (HBV) subtypes and HBV with mutant “a” determinant on the territory of the Russian Federation.

Worldwide, viral hepatites occupy rather high position in the list of infectious diseases with lethal outcome. Over 1.1 million patients died of viral hepatitis B only in 1995. The fact that about half of the patients of infectious clinics in Russia are hepatitis patients demonstrates the importance of these diseases for our country. In addition, hepatites B and C viruses are the second in the list of carcinogenic factors after smoking.

Within the frames of this Project, we plan to work out the methodology for detecting HBV subtypes and HBV with mutant “a” determinant on the territory of Novosibirsk region and spread it over all the Russian regions. This will allow the prevalences of hepatitis B virus subtypes and HBV with mutant “a” determinant in different regions of Russia to be clarified. This will be most important for improving and increasing the sensitivity of diagnostic means used in a particular region as well as for developing the strategy of hepatitis control.

The participants have experience in working with hepatitis A virus, including isolation of isolates, certification of viral strains, development of hepatitis A vaccine, and its production. In addition, the participants have developed diagnostic kits for detecting various markers of hepatites A, B, and C, HIV, etc., and have experience in diagnosing these infections.

On receiving of the ISTC funds, the executor will purchase the equipment and materials necessary for implementing the Project. The scheme of interactions with various medical organizations in order to obtain the samples will be worked out by the example of Novosibirsk region and the city. The techniques developed are then adapted to detect HBV subtypes and HBV with mutant “a” determinant in clinical samples.

After one year of the Project implementation, the data obtained will be analyzed and the experience accumulated on subtyping of HBV isolates and HBV with mutant “a” determinant are transferred to other regions of Russia.


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