Data Base on Allergic Diseases
New System of Automated Ecogenetic Database of Allergic Diseases
Tech Area / Field
- MED-DID/Diagnostics & Devices/Medicine
3 Approved without Funding
Scientific-research Institute of Pediatrics, Georgia, Tbilisi
- Asthma, Allergy & Clinical Immunology, USA, CA, San Francisco\nUniversity of Limerick, Ireland, Limerick\nTotal Research Institute on Allergy and Intractable Diseases/ YAOI Medical Clinic, Japan, Iwate\nUniversität Karlsruhe / Institut für Geographie und Geoökologie, Germany, Karlsruhe
Project summaryPrimary objective of the project is to create automated system of dynamic assessment of ecological and genetic risk factors in the formation of respiratory allergies.
A Second Objective of the project is to use ecogenetic database to improve the methods of prenozologic diagnosis (primary prognosis) of respiratory allergies in children and to establish effective module of preventive activities and optimal treatment.
Importance The high epidemiological indexes of allergic diseases and the high frequency of their formation in early age groups, multiple genetic and external factors of phenotypic expression dictate the necessity of integrative study and monitoring of ecogenetic characteristics of allergopathology.
At Present, it is widely recognized that hereditary predisposition is the main factor for the formation of respiratory allergies. And moreover in recent years the increase of frequency of respiratory allergies is the result significant atmospheric pollutants (carbon oxides, dioxides, sulphur, nitrogen, dust, and the product of partial burning of gasoline). In other words, many hereditary disorders result in diseases because of negative environmental factors. At present, a unified assessment system of the cumulative impact of eco- and endogenic factors of allergopathology in children does not exist on level of the population or the inpidual.
New and significant characteristic of the proposed project is that based on the structure of ecological risk (nature of operation, genesis, impact level, intensity – attributive risk, duration of impact – cumulative risk) and genetic markers (genealogical data, PI and ABO-genetic systems and other phenotypic markers) a scientific functional-technological monitoring system of casual links will be created in the formation and prognosis of allergic diseases in children.
Scientific Value of the project is that the resulting automated assessment system will provide opportunity to assess the impact of ecogenetic factors on the clinical progression of the disease; establish the priority of manageable factors; allow the creation of algorithms to assess the relationship between ecogenetic impact and level of sickness (frequency, structure, and clinical characteristics).
Practical Value of the project is that the resulting automated assessment new system will allow carrying out medico-ecological mapping of researched regions, processing personal data of genotypic and phenotypic characteristics and creating achievable, economical diagnostic and prevention methods of allergic diseases based on formalized cards.
Economical Value for Georgia and World Community is that proposed new system will reduce treatment costs of patients with allergic pathologies. It can be applied to other multifactoral diseases in different populations on all levels of medical services. The ecogenetic database can serve as an Information technology system for end users according to their abilities and goals.
The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.
ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.