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Human Tumors Pathology

#2957


The Information System of the Department of Human Tumors Pathology at Russian Cancer Research Center, RAMS, on Formalized Gross Descriptions of Different Gastrointestinal Tumors in Oncologic Patients

Tech Area / Field

  • MED-OTH/Other/Medicine
  • INF-DAT/Data Storage and Peripherals/Information and Communications
  • INF-SOF/Software/Information and Communications

Status
3 Approved without Funding

Registration date
17.12.2003

Leading Institute
Cancer Research Center, Russia, Moscow

Supporting institutes

  • NIIIT (Pulse Techniques), Russia, Moscow\nMIFI, Russia, Moscow

Collaborators

  • Niigata University / Graduate School of Medical and Dental Sciences, Japan, Niigata\nErnst-Moritz-Arndt-Universität Greifswald / Institut für Pathologie, Germany, Greifswald\nCureline, Inc., USA, CA, South San Francisco\nUniversity of Maryland at Baltimore / Medical Center, USA, MD, Baltimore

Project summary

The purpose of the Project is to create an information system for formalized gross descriptions of gastrointestinal tumors in cancer patients at the Department of Human Tumors Pathology, Russian Cancer Research Center, RAMS.

It is a common practice in cancer centers worldwide to make pathological reports in an arbitrary style. Descriptions of the same organ or tissue made by different pathologists may differ considerably. Degree of the difference varies depending upon pathologist's experience and inpidual mode of description of signs observed. Some signs considered insignificant by the pathologist may be missing. Description of the same sign may be different unless formal formats are developed. This situation makes information retrieval a difficult task.

When describing gross images of tumors, tissues and organs dissected from cancer patients the pathologist should use a set of formal gross descriptions.

Links to graphic files with images and applicable formalized descriptions will be stored as database tables on an SQL server. Final selection of software for the SQL server will be made during the project period. The following server versions are considered: Oracle 9i, MS SQL Server 2000, MySQL and PostgreSQL.

Patterns of formalized descriptions for gross images of tumors, tissues and organs dissected in cancer patients will be developed by the Department of Human Tumors Pathology, Russian Cancer Research Center.

The RCRC is the leading human cancer diagnosis institution in Russia. Results of about 130,000 pathology studies are added to its information system every year. Besides gross and microscopic descriptions, the information system contains about 300 gross images of most common cases.

The ATLANT telemedical computer complexes developed by the Department of Computer Medical Systems, Moscow Engineering Physics Institute, will be used to make the gross images.

The database (DB), a Windows application for DB editing, an on-line Case Search Engine will be developed by the Department of Software, Research Institute of Pulse Technique (RIPT). Earlier (2000 – 2002) specialists from this department developed an information system on tumor chemotherapy for the Russian Cancer Research Center, RAMS (ISTC Project #1342, http://oncology.niiit.ru). The US National Cancer Institute was the Project Collaborator. The NCI appraised highly the project progress and results. The ISTC requirement of engaging weapon specialists into civil activities will therefore be met.

Server and cross-connect equipment purchased earlier for the ISTC Project #1342 will be used in this project.

The information system will consist of a database (DB) with images of various surgical specimens and their formalized descriptions. The DB will be accessible via Internet. A DB information search engine will be located at a special WEB site. The WEB site will be made both in English and Russian. Internet queries can be generated on any set of database parameters. The answer will be a list of studies satisfying the search parameters. Patient data including sex, age, final diagnosis, histology code, topography code, gross and microscopic images and formalized descriptions for each case will be available for Internet users.

We also plan to use the software developed previously under ISTC Project #0052 “Hardware and software for medical wide area network”. Information from a cytology DB for each case will be available for Internet users. Formalized cytology descriptions will be made both in English and Russian.

The DB will be updated regularly with information about typical cases and original research. A special Windows application for DB editing will be developed. It will be installed on workstations at the Department of Human Tumors Pathology, Russian Cancer Research Center. A large number of studies performed at the Department of Human Tumors Pathology will ensure a fast DB growth.

Besides, DB structural information and access tools will be located on the WEB site. Thus, any organization will have an opportunity to create its own software to generate queries and display forms with search result. This technical approach was recommended by the NCI. A relational data model Developmental Therapeutics Program (http://dtp.nci.nih.gov/dw/dw_main.html) can be used as an example of DB presentation.

Besides, it is planned that authorized Internet users will be allowed to offer their versions of formalized gross descriptions. Thus, a wide circle of international specialists can contribute to refining formalized gross description patterns. Any cancer organization can create a similar DB for itself. As a result a global distributed DB will be created. This Project will be a part of common effort of international specialists to develop unified standards for formalized gross descriptions of organs as removed surgically in cancer patients.


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