Hypoxia and Magnetic Therapy for Personnel Radiation Protection
Development of Portable Normobaric Hypoxia and Pulsed Magnetic Field Firmware System for Enhancement of Radio- and Non-specific Resistance in Workers of Environmentally Hazardous Industries
Tech Area / Field
- ENV-EHS/Environmental Health and Safety/Environment
- MED-DID/Diagnostics & Devices/Medicine
3 Approved without Funding
Research Institute of Occupational Medicine, Russia, Moscow
- Russian Academy of Sciences / Institute of Radioengineering and Electronics, Russia, Moscow\nVNIIEF, Russia, N. Novgorod reg., Sarov
- Fraunhofer Institut Toxikologie und Experimentelle Mediwin, Germany, Hannover\nTrent University, Canada, ON, Peterborough\nUniversità di Roma "La Sapienza" / Dipartimento di Ingegneria Elettrica, Italy, Rome
Project summaryThe possibility to use physical factors to weaken acute and delayed radiation damage has always been attractive for radio-biologists.
The radio-protective effect of hypoxia has been known for quite along time, while the method of normobaric interval hypoxia has been used in clinical practice for more than 20 years. It proved to be highly efficient for the radiation therapy of oncological diseases.
A variety of hypo-toxic is Controlled Normobaric Interval Hypoxia (CNIH), i.e. imposing of interval hypoxia modes with account for inpidual condition of human organism based on automatically controlled patient’s respiration with hypoxic gas mixture. The CNIH is quite an advanced method for enhancing non-specific resistance (stability) of the organism to radiation, chemical, and biological impacts.
There are data that the CNIH might be efficient for the organism functional stimulation and rehabilitation in workers employed at nuclear, chemical and other hazardous production sites characterized by impeded respiration conditions, as well as in persons with bronchial/lung and cardio-vascular diseases.
The CNIH method enhances the organism survivability in altered environmental conditions and therefore it might be considered as a way to address severe ecological problems. However, the use of this method is limited with lack of available instrumental tools; firmware; and mature techniques. The CNIH may be easily combined with other methods aimed at the organism radio- and non-specific resistance enhancement, in particular, the method of pulsed low-intensity magnetic filed that is being actively developed now. The experimental data show not only a good synergy of using CNIH with other protective and prophylactic methods but also its potentio-static action.
In RFNC-VNIIEF under the ISTC Project #799-2 it was shown that low-intensity pulsed magnetic field (LPMF) with certain parameters and specifically modulated signal shape possesses a strong biological effect with respect to stem cells in “critical” cellular renewal systems; improves microcirculation; enhances the organism resistance to different harmful agents; and has specific radio-protective and radio-modifying effects.
The advantage of the present project is the development and practical use of a portable firmware system for combined CNIH and magnetotherapy action as a means of physical enhancement of non-specific and radio resistance in professionals employed in environmentally risky industries. At the initial stage of the Project the participating institutions will use stationary medical equipment certified by the Committee on New Medical Equipment of the RF Ministry for Public Health.
The goal of the Project is the development of a portable (mobile) firmware system and investigation of the bio-effects from the combined use of active aspiratory gas medium and LPMF, in order to enhance the radio- and nonspecific resistance of the organism.
The participating institutions are leading scientific organizations in RF in medical and social monitoring that possess the adequate capabilities and instrumentation required for designing sophisticated bio-medical systems.
The proposed Project fits within the technology development category. Its outcome will be the operational model of the portable firmware system for normobaric hypoxia and pulsed magnetic field therapy for the aforementioned applications. The system will allow providing prophylactic and rehabilitation measures practically at a target production site. This might substitute for more costly stationary methods, as well as upgrade the efficiency of conventional personnel protection means in emergency of accident clean-up. The projected indirect cost-effectiveness is connected with the disease incidence drop for 10-15%, longer professionally active age and less handicapping percentage in workers of environmentally hazardous industries.
The proposed project fully complies with the ISTC goals because it will provide alternative employment opportunities in civilian fundamental and applied R&D for specialists formerly involved into nuclear weapon development. The Project will address the following tasks, namely:
- Foundation of optimal CNIH and LPMF separate modes for protective, prophylactic and treatment applications intended for employees of nuclear and other environmentally harmful industries.
- Designing the multi-functional CNIH firmware system.
- Designing the multi-functional firmware system implementing combined CNIH/LPMF use.
- Foundation of approaches for combined CNIH/LPMF use aiming at human organism radio- and non-specific resistance enhancement.
- Trial CNIH/LPMF system operation.
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