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X-ray ARSA Irradiator

#2424


Development of a Pilot Model of Small-size X-ray ARSA Irradiator for Clinical Tests

Tech Area / Field

  • MED-RAD/Radiomedicine/Medicine
  • MED-OTH/Other/Medicine

Status
3 Approved without Funding

Registration date
18.02.2002

Leading Institute
VNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Applied X-rad Technology, USA, CO, Louisville\nUniversity of Florida, USA, FL, Gainesville

Project summary

ISTC Project №326 has been successfully completed with the X-ray irradiator developed basing on a small-size pulsed accelerator ARSA for medicine purposes. Good scientific and technical results proved by audit and technical monitoring on the side of ISTC Secretariat and acknowledged at six International conferences were obtained during the project implementation. Main engineering solutions of the development have been licensed according to the RF rules. Inventions “The method of irradiating biological objects, in particular, blood and its component” and “An X-ray Irradiator” received silver and bronze at the 47th Worldwide Exhibition of inventions and innovations (Brussels, Belgium, 4-11 November 1998).

The development is of scientific and practical value because of the urgent problem of donor blood irradiation during bone marrow transplantation and sterilization of medical articles and instruments. The environmentally safe X-ray irradiator developed is an alternative to radioactive isotopic irradiators (such as GAMMACELL-1000, MDS Nordion, Canada) and, hence, it can take its place among competitive products at the market of medical equipment.

Obvious advantages of the product are:

– quite radiation safety in shut-down state;


– biological shielding;
– compactness;
– easy transportation (this is a positive feature for sales);
– low cost.

Manufacture of a pilot model of X-ray irradiator was not provided for by Project №326. According to the work plan, efforts under the project were accomplished with the irradiator laboratory model features examined and detail design documents issued. Within the period from the project completion time up to present days, experts from companies producing irradiators for medicine (MDS Nordion, Canada; RAD-Source, USA) were intensivle consulted. Consultations resulted in additional requirements placed upon the irradiator, the recognized need in development of a prototype model and its clinical tests. There are the following reasons for further development of Project №326 efforts:

– the RF Ministry of Public Health has granted permission to develop an irradiator;


– a co-executor for medical investigations is found: KNIIGPK (Kirov), one of the leading Russian hematological centers;
– scores of requests for a such-type device have been obtained from medical institutions (clinics, hospitals, hematological centers, institutes), including those abroad;
– of most importance is the fact that foreign collaborators under the project are well-known experts in the area of interest:
G. Georgiev, Rad-Source Technology Inc., USA (radiation facilities for blood and food);
J.S. Tulenko, Nuclear and Radiological Engineering Department, University of Florida, USA.

The project goal is to develop, manufacture and clinically test a pilot model of a small-size X-ray ARSA irradiator that is an alternative to radioactive isotopic irradiators (for further development of ISTC project #326 efforts).

Purpose and area of application:

– donor blood irradiation;


– surface dterilization of mecicine tools and items;
– radiobiological research.

The experiments performed allow the expectation that an irradiator to be developed (with slight modifications to it) could be successfully used in other areas, for example, to control parameters of the radiation-resistant element base in microelectronics during the technological cycle of manufacturing it.

Brief description and main specifications.

An X-ray irradiator was developed using high technologies and basing on the many-year RFNC-VNIIEF practice in the area of accelerating pulse devices. An irradiator provides double-side irradiation of items and is based on small-size direct-action accelerators using 350 kV Tesla transformer circuit. For medicine purposes, an irradiator is supplied with local biological shield, a programmable control console and a monitor-dosimeter for prompt dose rate control.

Specifications:

– dose absorbed by an irradiated object for 5 minutes, Gy 15


– maximum X-ray quantum energy, keV 350
– radiation field diameter, mm 120
– dimension, mm 800×450×1480
– mass, kg 170
– power consumption, kW 0.5
– power supply, V/Hz 220/50

The following activities are anticipated during the project period:

– development of design and manufacturing process documents;


– manufacturing pilot models;
– laboratory tests, examination of output electrical and radiative parameters of the irradiator;
– execution of patents required;
– acceptance tests;
– clinical tests;
– marketing studies;
– issue of a final report.

The proposed project efforts are based on RFNC-VNIIEF personnel skill gained for many-year developments of small-size pulsed accelerators. The project executors have the required skills in manufacturing unique units for those accelerators (high-pressure discharges, pulsed X-ray tubes, high-voltage pulsed transformers), as well as in dosimetry studies, calculations of X-ray spectra and energy release in irradiated objects, that have been demonstrated during the ISTC Project #326 implementation.

The proposed project fully meets the ISTC goals:

– it is the most advanced physical-and-technical development having prospects of its further successful use in many peaceful-purpose research areas, primarily, in medicine;


– the expected project result is of high commercial potential and it undoubtedly promotes transition to the market economy;
– the project involves scientists and enfgineers previously enfgaged in Russian nuclear weapons development and production into the international scientific community.


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