Simultaneous Action of Radiation and Heating on Tumor
Further Progress of Research and Development of Methods and Equipment for Simultaneous Action of Radiation and Heating (SARH) on Tumors for Increasing Therapeutic Effect
Tech Area / Field
8 Project completed
Senior Project Manager
Melnikov V G
MIFI, Russia, Moscow
- NPO ISTOK, Russia, Moscow reg., Fryazino\nCancer Research Center, Russia, Moscow\nVNIIEF, Russia, N. Novgorod reg., Sarov
- Erasmus University, The Netherlands, Rotterdam\nUniversity of Amsterdam / Academic Medical Center, The Netherlands, Amsterdam
Project summaryThe purpose of the present offers on continuation of the work started and successfully executed in ISTC Project #2221, is optimization of increasing effectiveness and widening application fields of a remote simultaneous action of radiation and heating (SARH) on malignant tumors – a new advanced method of treatment for oncology diseases. SARH provides the increase of ionizing γ-radiation action being reinforced due to thermal effect (RTE).
In the process of carrying out ISTC Project #2221 methods and applicators providing simultaneous heating (hyperthermia) of tumor and its irradiation by ionizing radiation were developed. The developed applicators operate at 434 MHz electromagnetic oscillations (EM) frequency, and their design and geometric size allow to heat vast subsurface malignant tumors up to 43 - 44 ˚C simultaneously with their -irradiation.
We propose the development of electromagnetic applicators and their complexes (phased arrays) as well as methods of heating tissues capable to create heating areas with a preset configuration both across the surface and in depth of the heated tissue volume. To heat subsurface and rather deeply located tumors 434 MHz heating frequency was chosen. For applicators designed for heating deeply located tumors 70 MHz frequency was chosen. Such applicators working at 70 MHz frequency are capable to concentrate EM energy in the preset volume of deeply located tumors due to phase and amplitude control of each separate applicator.
The applicators are based on three-layer material FF-4, consisting of two layers of copper foil 35m thick each, and one fluoroplastic layer 1.5 mm thick between them. By its design the applicator consists of antenna built in a rubber water bolus, the antenna is made of FF-4 material by photolithography method with a certain pattern of copper foil.
The task of the new Project is to create a series of applicators made on one substrate (from one sheet of FF-4 material) consisting of several antennas and controlled both by high-frequency power applied onto them and phase shift of electromagnetic fields between certain antennas. Thus, the applicator will acquire new unique possibilities of both selective heating of complicated in shape tumors in applicator aperture plane and a possibility to adjust the heating depth in biological tissues due to phase addition of electromagnetic fields from separate antennas of applicators in pathologic tissues. Besides, the applicators must be flexible to fit bends of a body.
Applicator will be added with system of monitoring of surface doses of an ionizing radiation on a body of the patient for the account of indignations because of a variation of thickness of cooling water in bolus. Also will be developed the procedure of calculation of thermal fields in biological tissues at absorption of EM energy. The system of dosimetry planning will be developed in view of new applicators design and new sources of ionizing radiation.
For an objective estimation of synergetic action of ionizing radiation and heating of tumor tissues will be carried out experiments on studying clonogenicity (survival rate) in different modes of heating and an irradiation. Optimization of the schedule for the treatment by hyperthermia and radiation will be done based on in vitro and in vivo experiments. Results of experiments will form base for definition of efficiency of various modes with the help of mathematical models of fuzzy mathematics and neural networks.
The work on the Project is supposed to be fulfilled by solving 6 main tasks:
- Theoretical and experimental research and development of electromagnetic hyperthermia radiators with a controlled intensity of tumor heating allowing its simultaneous non-distorted irradiation of ionizing radiation.
- Development of the dosimetry block, providing precision measurement of a surface radiation doses (and its distribution) during SAHR.
- Development of the program module for a fast and accurate calculation of dose distributions based on Monte Carlo method.
- Biological experiments on laboratory animals with tumors to assess synergetic effect of simultaneous hyperthermia and irradiation of ionizing radiation.
- Development of experimental data processing and modeling of cell survival under hyperthermia and radiotherapy of tumour.
- Development of the effective calculation algorithms for planning and controlling of a heat energy distribution in heterogeneous tissues.
Foreign specialists from leading oncology institutes of the Netherlands take part in the Project jointly with a Russian team as far as information exchange, assessment of technical reports, joint seminars and working consultations are concerned.
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