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Study of Highly Dangerous Viral Pathogens in Georgia

#G-2189


Determination and Seroprevalence Study of Genetic Diversity of SFTS and CCHF Among of Farming Animals, rodents and in Tick Species in Georgia

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology

Status
3 Approved without Funding

Registration date
15.04.2015

Leading Institute
National Center for Diseases Control, Georgia, Tbilisi

Collaborators

  • National Institute of Infectious Diseases / Special Pathogens Laboratory, Japan, Tokyo

Project summary

The proposed collaborative research project will assess the prevalence among of farming animals and genetic persity of highly pathogenic Bunyaviruses in Country of Georgia which includes Crimean Congo hemorrhagic fever virus (CCHFV) and Severe Fever with Thrombocytopenia Syndrome (SFTS).
The work will build on earlier and ongoing surveillance studies within Georgia by providing more detailed characterization of CCHFV and finding of SFTS types. In addition, active bio-surveillance of rodents and ticks from an area of Georgia where a recent CCHF outbreak occurred and close to GEO-Turkey border area will provide a baseline assessment of the potential for future outbreaks of CCHFV and will show whether the SFTS is circulating and/or is endemic to this region. Viral antigens and RNA identified in existing samples, or those collected from rodents or ticks will be characterized by immunoassays and gene sequencing by Sanger method. Sustainable molecular diagnostic assays will be implemented. Georgian personnel will be trained to perform these assays and to produce necessary reagents in the collaborative Institution in Tokyo, Japan. These studies will fill knowledge gaps concerning the disease potential of bunyaviruses causing hemorrhagic fevers in Georgia and will advance the capabilities of laboratory personnel to enable future collaborative studies that will sustain the laboratory. SFTS is an emerging infectious disease with a high case fatality risk and is caused by the SFTS virus (SFTSV) and it has a great importance for whole Eastern Europe to study whether SFTSV is circulating in Georgia. SFTSV readily infects humans with farming-related exposures as well as numerous domestic and wild animals. A conventional one-step reverse transcription-PCR (RT-PCR) (cvPCR) method and a quantitative one-step RT-PCR (qPCR) method were developed to detect the SFTSV genome by our Japanese collaborators, which will be used as a major and powerful diagnostic tool in scopes of this project.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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