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Antiviral Properties of Excilamps

#3962


Study of Antiviral Properties of Excimer Light Sources

Tech Area / Field

  • PHY-OPL/Optics and Lasers/Physics
  • BIO-MIB/Microbiology/Biotechnology
  • ENV-WPC/Water Pollution and Control/Environment
  • OTH-ELE/Electrotechnology/Other

Status
3 Approved without Funding

Registration date
01.04.2009

Leading Institute
Vavilov State Optical Institute (GOI), Russia, St Petersburg

Supporting institutes

  • RAMS / Research Institute of Influenza, Russia, St Petersburg\nSiberian Branch of RAS / Institute of High Current Electronics, Russia, Tomsk reg., Tomsk

Collaborators

  • Saga University, Japan, Saga\nKERI - Korea Electrotechnology Research Institute / SOI-KOREA Center, Korea, Gyeonggi-do\nTechnische Universität München / Physik Department E-12, Germany, Garching\nUniversity of Toronto / Department of Electrical & Computer Engineering, Canada, ON, Toronto\nLos Alamos National Laboratory / Bioscience Division, USA, NM, Los-Alamos\nURA 0073/Universite Paris-Sud / Laboratoire de Physique dez Gaz et des Plasmas, France, Orsay\nUniversite Paul Sabatier / Laboratoire Plasma et Conversion d'Energie, France, Toulouse

Project summary

The main purpose of the project is to study the inactivation of different viruses under the influence of light radiation in the range of 120-350 nm and to create the unit prototype for inactivation of viruses pathogenic for humans. The project will result in the scientific basis for development of technologies for virus inactivation in the aqueous media and on surfaces, as well as in new methods of optical influence on viruses.

Pathogens to be examined will include viruses representing the most actual groups from the point of view of the virion and genome organization. Influenza virus representing enveloped RNA-genome viruses (to which also the viruses of avian influenza belong), herpes virus (DNA-genome enveloped virus) and human adenovirus, (non-enveloped DNA-genome virus), will be used in experiments. The broad range of the excilamp-generated radiation wavelength will allow to study in detail the influence of radiation of the first maximum of DNA-molecule absorption wavelength, which include the wavelength of radiation (254 nm) of the routinely used mercury lamps. Besides that, the project will give a new results concerning the influence of irradiation in the range of the second maximum of the DNA-molecule absorption (λ~200 nm) and also the data on the verocidal action of the vacuum UV-range (120-200 nm). Thus, the project will solve both fundamental and applied problems.

At present, conventional mercury lamps and xenon pulse lamps are used for the disinfection. Substantial disadvantages of mercury lamps are the risk of environmental contamination by vapors and the necessity to utilize used lamps. In the Project under consideration, comparatively new sources of spontaneous radiation, namely excilamps, are suggested for the use. The advantages of excilamps are the broad spectrum of the wavelengths, which is determined by the composition of the working mixture and is in the range of 120 nm - 350 nm, and quick adjustment of the stationary mode (less than a second). Besides that, the excilamps allow to provide the irradiation of surfaces of different shapes and sizes.

The urgency of search for the means to prevent virus epidemics is dictated also by development of a prepandemic situation in the world and the danger of appearance of new virus agents in the human population, against which there are no vaccines, chemical preparations and collective immunity. Such viruses include, in particular, the highly pathogenic strains of the influenza virus (avian influenza of H5N1 subtype) and enteroviruses of 71 type. These influenza strains have caused the recent outreaks of diseases with numerous lethal outcomes. The obtained results will allow to develop a new methodical approaches to the prophylaxis of influenza and substantially reduce the possibility of virus infection and the danger of pandemic caused in human population by pathogenic viruses, in particular by avian influenza virus.

The leading Russian specialists on excimer lamps from S.I. Vavilov State Optical Institute (St-Petersburg), Institute of High Current Electronics SB RAS (Tomsk) and leading virologists from Research Institute of Influenza RAMS (St-Petersburg) will participate in the Project. The participants of the Project have necessary experience for carrying out of the work and are the authors of more than 200 works in the fields covered by Project. About 60% of the Project participants belong to the category of “weapon scientists”. Scientists from EU (France, Germany) working in the areas of investigation, development and application of ultraviolet light sources will take part in the Project as collaborators.


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