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Antioxidant Therapy and Drug Resistant Tuberculosis

#A-1902


Drug Resistant Tuberculosis and Therapeutic Effectiveness of Newly Synthesized Compounds with Antioxidant Activity

Tech Area / Field

  • AGR-DIS/Disease Surveillance/Agriculture
  • BIO-CHM/Biochemistry/Biotechnology
  • BIO-MIB/Microbiology/Biotechnology
  • BIO-SFS/Biosafety and BioSecurity/Biotechnology
  • MED-DRG/Drug Discovery/Medicine

Status
3 Approved without Funding

Registration date
13.10.2010

Leading Institute
Scientific Technological Center of Organic and Pharmaceutical Chemistry, Armenia, Yerevan

Collaborators

  • Koch-Metschnikow-Forum, Germany, Berlin\nPittsburgh University / Graduate School of Public Health / Department of Environmental and Occupational Health, USA, PA, Pittsburgh\nEuropean Academy of Natural Sciences, Germany, Hannover\nUniversity of Aberdeen / Rowett Institute of Nutrition and Health, UK, Aberdeen

Project summary

We propose to use some preparations which could be useful in repair processes and active in increase of immunity at drug resistant tuberculosis (DRT) of lungs. One of mentioned substances is Larifan (ds-RNA) and its calcium precipitate (Ca2+-ds-RNA), entitled “Zetapol”, which was synthesized by a group of scientists from the Armenian National Academy of Sciences. “Zetapol” is a very good remedy with antimicrobial and antiviral properties, being able to increase the non-specific resistance of the organism and to induce the activity of tissue interferon on the level of molecular mechanisms.

One of the main purposes of the project offered is to carry out nucleosides synthesis of pyrimidine nature, as well as of analogues of natural antibiotics such as sparcomycine, tubercidin, sangivamycin et str. and to conduct wide investigations on therapeutic effectiveness of aciclonucleosites such as acyclovir analogues, which may cause a significant interest in DRT clinic, as very active compounds with prophylactic and antibacterial properties.

The investigations will be directed to studying the impact of newly synthesized compounds mentioned on disorders of phospholipid metabolism, free radical oxidation of lipids, as well as blood coagulation processes, damaged with DRT in the experimental and clinical issues.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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