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Blood Protection

#2354


Blood Protection in Cardiosurgery

Tech Area / Field

  • MED-OTH/Other/Medicine
  • MED-DID/Diagnostics & Devices/Medicine

Status
8 Project completed

Registration date
02.11.2001

Completion date
11.04.2005

Senior Project Manager
Lapidus O V

Leading Institute
Research Institute of Technology, Russia, Leningrad reg., Sosnovy Bor

Supporting institutes

  • Medical Academy of Postgraduate Education, Russia, St Petersburg

Collaborators

  • Mayo Clinic / Division of Cardiovascular Surgery, USA, MN, Rochester

Project summary

The purpose of this project


Design of prototype hemoprotection devices, their physical, chemical, and biological testing under laboratory conditions, and limited clinical trials.

Problem

According to WHO statistics, about 50 cardiac operations are required worldwide per 100,000 people.
Continuous artificial circulation of blood is required for cardiac operations. A number of adverse factors associated with artificial circulation affect the blood and result in the destruction of the formed elements, particularly, erythrocytes. They are replaced by introducing donor’s blood, which differs from that of the patient in chemical and biological characteristics. This leads to an increased period of postoperative rehabilitation.
Major goals

Ш Enhanced resistance of the formed elements of patient’s and donor’s blood to adverse factors of continuous artificial blood circulation during cardiac operations.
Ш Treatment of patient’s blood with perfluororganic compounds, either before or during an operation.
Ш Lower susceptibility of the formed elements of patient’s and donor’s blood to injury and destruction during heart operations and, concurrently, increased oxygen transport.
Ш Reduced demand for donor’s blood.
Ш Reduced postoperative rehabilitation time.


Expected results and their application

The estimated project duration is two and a half years.


For the first year, it is planned to develop a procedure for extracorporal interaction of blood with perfluororganic compounds, to design and manufacture model prototypes of hemoprotective devices.
For the second year, it is planned to investigate physico-chemical and medico-biological characteristics of the hemoprotector model prototypes under laboratory conditions.
In the first half of the third project year the authors plan to conduct limited clinical trials of the hemoprotectors.

Based on the project research results, the research team will issue reports, prepare papers for publication in scientific-technical and medical literature, prepare, if necessary, patent applications, carry out preliminary market research, and decide on countries for potential patenting.
Meeting ISTC Goals and Objectives

The project will provide weapons scientists and engineers with the opportunity to participate in basic and applied research and technology development for peaceful purposes, notably in the field of medicine, and it will promote the integration of Russian scientists into the international scientific community and strengthen the scientific potential of Russia.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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