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Bioinjuries Protection of Industrial materials

#3276


Protection Biotechnology of Industrial Materials from Mycoinjuries by Using Biofugicides

Tech Area / Field

  • ENV-RED/Remediation and Decontamination/Environment
  • BIO-MIB/Microbiology/Biotechnology
  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-IND/Industrial Biotechnology/Biotechnology
  • BIO-DIV/Biodiversity/Biotechnology

Status
3 Approved without Funding

Registration date
06.05.2005

Leading Institute
Research Center of Toxicology and Hygienic Regulation of Biopreparations, Russia, Moscow reg., Serpukhov

Supporting institutes

  • Russian Academy of Sciences / Center for Ecological Safety, Russia, St Petersburg

Collaborators

  • Ludwig-Maximilians-Universität / Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Germany, Munich\nTufts University, USA, MA, Boston

Project summary

Bioinjuries protection is a global scientifically–practical problem. Humanity has considerable losses because of distraction of culture memorials, books, works of art and others with funguses, which generate mold. Bioinjuries damages amount to 7 % of total industrial production value on an international scale.

Bioinjuries protection of military regimentals (outer clothing, underwear), leather products (belts, holsters, covers, etc.) have a great value in conditions of high humidity and temperature. It's also a necessary storage condition of military property in warehouses in conditions of a hot, tropical climate. Materials, treated with biofungicides, are less injured by molds; term of their safe storage is extended. Besides, molds, which are multiplied on regimentals, form spores, which cause allergic reactions in military men.

Widely distributed bioinjuries agents of different materials, its products, constructions are microorganisms and, first of all, funguses (micromicete).

To present day the main protective method from micoinjuries in our country and abroad is the use of substances, being got as a result of synthesis and called fungicides. However, only few substances are used in practice because of lack of its correspondences: such as purity, harmlessness for human being and animals.

On account of difficulties of search and creating of fungicides, which will be met strict and constantly increasing environmental requirement, on account of variety agents, materials, being made by man, variety its storage and service conditions, the deficiency of protection means from mycoinjuries is high and constantly increases. Besides, in most cases, the fair quantity of protective compounds are necessary – so the use of chemical synthesis products becomes economically unprofitable and at the same time it leads to environment pollution.

Advanced solution of this problem is search of biofungicides among substances in nature. Some metabolism products of many microorganisms–antagonists of funguses belong to them. In contrast to chemical agents, biofungicides are highly–effective, have specificity of actions, don't apply to xenobiotics and not accumulate in nature; technology of its receiving is simple and can be realized in different scales without particular problems.

Investigations of using such products–antibiotics, enzymes, volatile matters and others for fighting against moulds, carried out in Russia and other countries, prove the advisability of holding investigations for searching and receiving of ecological pure means for prophylaxis and fighting against mycoinjuries of industrial materials. Important advantage of the most such preparation is that they don't accumulate in nature, creating pollution threat, but they, like many biological compounds, take part in the metabolite cycle where they are destroyed.

The goal of the project is development of technology for receiving ecological pure biofungicides for fighting against mycoinjuries of industrial materials by isolation and selection of highly–effective strains of microorganisms–producers of antifungal substances.

Microorganisms are proposed to isolate from soils of different climatic zones for further selection of biofungicides producers. Then, it is planned the identification of microbes–antagonists and its isolated biofungicides, definition of its novelty.

One of the sections of the project will be devoted to study the character and degree of influence of biofungicides on physiology–biochemical properties of molds and, first of all, on substances formation by funguses, under the influence of which, bioinjuries (enzymes, organic acid, pigments) are realized.

The main technological process stages of receiving of biofungicides will be developed and optimized.

Toxicological studies of microorganisms–producers and biofungicides on harmlessness for warm–blooded animals will be conducted on laboratory animals (white mice and rats)

With the aim to assess efficacy of derivable antifungal substances they will be tested as possible properties for protection from mycoinjuries of industrial materials of different chemical nature. The results of the laboratory trials will be used for working out methods of practical uses of antifungal substances.

Collective of project contributors – researchers consists of microbiologists, biochemists, chemists, toxicologists, ecologists and biotechnologists who have experience in isolation of microorganisms–producers of different biologically active substances from ecosystem and creation of technology for their production.

Methods of isolation and selection of strains of microorganisms–producers of different substances, including antibiotics, lytic enzymes, pigments, organic acids, and others, are worked out in SRCES and the biotechnology for receiving of products of microbial synthesis is also working up here. Investigations of physiology–biochemical properties of funguses, which are produced bioinjuries, are conducted on high–professional level and methods of regulation of its metabolic activity are working out. Protective device for cellulose materials is approved in the great museums and libraries of Russia (The Hermitage, RAS Library, Russian National Library), Russian patent # 2048007 has been drawn up on this device.

SRCES has well–equipping analytical laboratory for study biochemical activity of microorganisms, analysis of formed biofungicides.

RCT&HRB has got the laboratory base for toxicological investigations (vivarium complex), which is corresponded to international GLP standard, is supplied with necessary equipment, and the laboratory personnel has been trained in the USA and Russia issues of human treatment of laboratory animals. The investigations are planned to conduct on laboratory animals (white mice and rats) by the strictest criteria accepted in world practice to assess harmlessness of microorganisms–producers of medical drugs. These criteria are virulence, toxicity, toxigenicity and dissemination in organs and tissues of laboratory animals. Evaluation of toxicological properties of microorganisms-producers will allow selecting strains safe for warm-blooded animals and humans.


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