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Optical Tomography for Medicine

#0280


Development of the Instruments for Optical 3D-Intrascopy-Medical Optical Tomography.

Tech Area / Field

  • PHY-OPL/Optics and Lasers/Physics

Status
8 Project completed

Registration date
26.10.1994

Completion date
31.03.2004

Senior Project Manager
Kirichenko V V

Leading Institute
Research Institute for Laser Physics, Russia, St Petersburg

Supporting institutes

  • VNIITF, Russia, Chelyabinsk reg., Snezhinsk\nRussian Academy of Sciences / Physical Technical Institute, Russia, St Petersburg

Collaborators

  • Universität Ulm / Institut für Lasertechnologien in der /Medizin und Messtechnik, Germany, Ulm\nNorwegian University of Science and Technology, Norway, Trondheim\nUniversity of Pennsylvania, USA, PA, Philadelphia\nUniversity of Connecticut, USA, CT, Storrs\nUniversity of Hertfordshire, UK, Herts, Hartfield

Project summary

The present proposal is the part of the version of ISTC Project #280 submitted earlier. This part presented as an Independent Project. The basic tasks which are identified by the proponents for this Project are the problems connected primarily with the systems of the "thick-layer" tomography. It includes also some questions representing interest for MOT systems working with "thin-layer" objects (definitions of "thin-layer" and "thick-layer" tomography see Sec. 2.3V

Main tasks of the project:

The present Project is aimed to the development of scientific background of optical images retrieving, development of the computer software enabling the images retrieving, and development of promising laser sources for the tasks of medical optical tomography.

The basic goals of the Project are:

• Development of algorithm for high-speed real-time computer tomographic reconstruction of optical structure of biological objects with high image resolution.

• Development of the computer software enabling the optimal measurements and processing of data obtained.

• Development of principles of spectrum-correlation tomography of biological objects.

• Development of picosecond diode laser sources with high average and pulse power.

Within the framework of the Project the following particular tasks are pursued:

Development of computer algorithms

Theoretical and experimental study of the statistical characteristics of multiple scattered photons' trajectories propagating in homogeneous and inhomogeneous tissue-like bodies of various shapes, for the cases of short-pulse and sine-modulated CW point light sources, in the different approximation of the radiation transfer equation.Theoretical substantiation of using the multiple scattered components of light for the study of under-surface layers of biotissues with the thickness up to 10mm by the method' of optical sounding.

Development of high-speed mean-trajectory algorithms of optical with the increased image resolution

Computer software

Development of the applied programs ensuring real-time multi-aspect reconstruction for the pulse and difluse-wave MOT systems and allowing the user to optimize the measurements conditions for achievement of the best quality of the reconstructed images.

Spectrum-correlation tomography (SCT)

Theoretical substantiation of SCT methods for the cases of registration non-scattered and multiple scattered light components, as alternative to MOT methods using time-resolved optical signals registration.Theoretical and experimental study of thin-layer SCT on the basis of real-time record and reading of the spectral holograms (2D pictures of spectral interference) with restoration of three-dimensional structure of layers of biological tissue using the optical correlation processing.

Picosecond diode laser

Studies of conditions and mechanisms of formation of powerful picosecond optical pulses by semi-conductor lasers of a various design operating in Q-switch mode using saturable absorber created by implantation of heavy high-energy ions.Optimization of parameters and design of picosecond semi-conductor lasers with high average power for the tasks of optical tomography.


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