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Ion Trap Mass Spectrometer


Development of New Technology of Mass-Spectrometry for an Ion Trap Mass-Spectrometer (ITMS)

Tech Area / Field

  • INS-MEA/Measuring Instruments/Instrumentation

3 Approved without Funding

Registration date

Leading Institute
NIIIT (Pulse Techniques), Russia, Moscow

Supporting institutes

  • HELP, Inc., Russia, Moscow


  • Textronica AG, Switzerland, Oberriet\nFinnigan Mat / The Mass Spectrometry Company, UK, Hemel Hempstead\nUniversity of Houston / Department of Chemistry, USA, TX, Houston

Project summary

A objectives of the project is the development of technology of mass-spectrometry of organic compounds, realized in modern Ion-Trap Mass-Spectrometers (ITMS), used as a detector for Gas Chromatograph, which is a part of GC-MS system.

As an experimental background, the project would apply one of the newest type of Ion-Trap Mass Spectrometers.

The development of MS technology, realized in ITMS suppose the decision of the following problems:

1. Increasing the number of ionization methods by resonance capture of electrons by molecules of all organic analyts followed by registration of negative doughtier ions.

A mass-spectrometry of positive ions of all organic analyts, which was realized for the first on the Ion-Trap type mass-spectrometers, uses two methods of ionization-electron impact (El) and chemical ionization (CI).

2. Designing a flash-thermodesorber and integrating it in GC-MS system for analysis of air pollutants collected in adsorption tube from environmental air, technologically pure gases, industrial waste gases and other gaseous analyts. The desorption time will not exceed several seconds.
3. Working out the analytical technique for this novel GC-MS system.

Any GC-MS system with advanced technology of mass-spectrometery and Flash-Thermodesorber will provide:

- the obtaining and registration mass-spectra (for all organic analyts) of both positive and negative ions simultaneously and to process them;
- the decreasing of practical quantitation limit due to negative ionization by a factor of not less then 20 as compared with positive ions in the mode of selective ion monitoring for the analyts of pointed class;
- the distinguishing of substances which produce very similar positive mass-spectra but different negative mass-spectra, for example, some structural isomers;
- the obtaining and using much additional information about analyt due to energy spectra of negative ion output vs. Electron energy;
- the dispensing with cryo-focusing equipment, which is known to be expensive,
- time-consuming, difficult in use, and required a lot of liquid nitrogen;
- the realization of direct input of preadsorbed substances from air into mass-spectrometer using Flash-Thermodesorber and identification them, using Selective Ion Monitoring mode for selected positive and negative ions.
This might be very useful in customs examination for detection of drugs, explosives, and toxic chemicals.

Realization of this project will ensure alternative occupation of scientists and engineers connected with weapon development in there civil activity.

Potential role of foreign collaborators

Foreign collaborators:

- support the main ideas of the presented project, that essentially enhance the analytical capabilities of GC-MS system;
- consider the suggested improvement of MS technology to be actual and technically executable;
- express personal interest to use the obtained scientific and technical results on the concrete GC-MS system;
- take part in the discussing of technical decisions, suggested by the authors during project execution;
- are ready to take part in working out the analytical technique to analyze complex multicompound organic mixtures on the advanced GC-MS system.


The development of modern technology of mass-spectrometry, by obtaining in the device mass-spectra of the negative ions for all organic analyts with the use of ionization method of resonance capture of electrons, can be realized not only in GC-MS system with ITMS, but also in the one with mass-spectrometer with quadrupole mass filter.

Flash Thermodesorber can also be applied to any GC and any GC-MS system.


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