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Electromagnetic Radiation Effects on Hemorragic Fever Virus

#G-480


Biologic Effectiveness of Electromagnetic Radiation on Certain Pathogens of Hemorrhagic Fever

Tech Area / Field

  • MED-DID/Diagnostics & Devices/Medicine
  • BIO-MIB/Microbiology/Biotechnology
  • ENV-EHS/Environmental Health and Safety/Environment

Status
3 Approved without Funding

Registration date
01.03.2000

Leading Institute
Georgian National Center for Disease Control, Georgia, Tbilisi

Collaborators

  • University of Minnesota / School of Public Health, USA, MN, St Paul

Project summary

Many scientists link epidemic outbreaks with the occurrence of various major environmental variations. Both oppression and activation of replication and virus infectiousness are of specific interest for certain sectors, of e.g. defense industry, vaccine development and production, and treatment of virus diseases.

The goal of the Project is to determine the latitude of purposeful impact of physical factors on the pathogens of certain infections by experimental methods involving electromagnetic radiation to study their effect on viability of a group of viruses causing hemorrhagic fever.

The following viruses have been chosen for the research: Yellow Fever, Dengue Fever, Rift Valley Fever, and Crimea-Congo Fever.

Since 1980, different viruses have been studied at Georgian Antiplague Station (a USSR defense subject-matter) under the USSR Ministry of Health (presently – Georgian National Center for Disease Control). In 1990, on request of the Ministry of Health of Georgia, there was initiated a study of the impact of physical factors on viability of certain viruses. Papers published on the subject-matter 1 – 12 have indicated active impact of electromagnetic fields on viability of viruses, both in cell culture and in vivo experiments (animals). Due to hard economic situation of the country and lack of funds for science, all research work in the above field was suspended.


The results of previous research provide the basis for setting the main objectives of the Project:
1. To determine effective ranges of electromagnetic radiation on virus viability in cell cultures;
2. To define limits to electromagnetic radiation for in vivo experiments;
3. Recommend practical impacts of the results in various fields of medicine.

Yellow Fever (YF) – causes a disease accompanied by intoxication syndrome development – with systemic lesions of capillaries and liver. The virus pertains to Flaviviridae family of viruses. Its size is 38 nm. The virus has a spherical form of composite make-up. It has a supercapside membrane containing glyco- and lipoproteins. A single-spiral RNA represents the virus’s gene and the virus agglutinates geese erythrocytes. The virus reproduction results in cytopathic effect. The virus grows in transfuse culture.

Dengue Fever (DF) – an independent nosologic form, causes system hemorrhagic lesion, accompanied by shock syndrome. The viruses belong to the family Flaviviridae. Have spherical shape, 50 nm in size having lipid-containing supercapside with distinctive protuberances. The viruses are sensitive to fat solvents, very labile and maintain infectiousness only in the presence of stabilizers. A single-spiral RNA represents the virus gene.

The viruses agglutinate birds’ erythrocytes, are reproduced in transfuse cellular structures and animal organisms.

Rift Valley Fever (RVF) – infects humans and cattle. Belongs to the family Boulliaridae. The gene is represented by a single-spiral RNA. Nucleotides unite on the intra-plasmatic membrane.

Crimea-Congo Fever (CCF) - Infects humans and cattle. Belongs to the family Boulliaridae. The gene is represented by a single-spiral RNA. Nucleotides unite on the intra-plasmatic membrane, which is characteristic to all viruses belonging to the family Boulliaridae.

Stages of the Study:


1. Study of the effectiveness of electromagnetic radiation on virus viability
A virus – cell system exposed to various mode electromagnetic radiation will be studied. The virus infected cellular culture will be subjected to the experiments. The virus – cell system will be studied, both together and separately under electromagnetic radiation.

2. Electromagnetic radiation in vivo


The determined characteristics of electromagnetic radiation will be used for the infectiousness study in experiments with mature mice. A quantitative analysis of antigens and antibodies in animal organism will be carried out.

3. Analyses


Possibilities of virus activation and deactivation, potentialities of curative and preventive use of electromagnetic radiation of the given range will be determined. A theoretical analysis of low-intensity electromagnetic radiation effect on biosystems will be given and practical recommendations on the use of the studied effects in different applications will be presented.


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