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Biological Efficiency of Beta-Emission

#0700


Health-Biological Study of Tritium and Tritium Oxide Effect on Human Organism. Experimental Estimation of Tritium Beta Emission Relative Biological Effectiveness by Cytogenetic Criteria

Tech Area / Field

  • BIO-OTH/Other/Biotechnology

Status
8 Project completed

Registration date
16.07.1996

Completion date
22.11.1998

Senior Project Manager
Nietzold D

Leading Institute
VNIIEF, Russia, N. Novgorod reg., Sarov

Collaborators

  • Lawrence Livermore National Laboratory, USA, CA, Livermore

Project summary

The project is devoted to studying the biological effect of tritium and tritium compounds on a human organism which currently provokes an enhanced interest. This is due to, first, the considerable increase in tritium content in the environment; second, some peculiarities of tritium effect on biological molecules and insufficient understanding of the biological tritium effect on a human body within the low dose range.

The project includes a section devoted to research into tritium and tritium oxide assimilation by the human organism at various intake paths (inhalation, peroral and percutaneous).

Owing to the urgency of studying the delayed tritium effects on the human organism, the project provides for epidemiological research into malignant neoplasms and study of the general somatical morbidity within a group of professionals working under conditions of the tritium and tritium oxide effect.

To conduct computations of permissible irradiation levels under various conditions in order to prevent overirradiation of people and environment contamination, it is necessary to know the values of tritium relative biological effectiveness factors. The project provides for experimental estimation of tritium relative biological effectiveness by cytogenetic criteria in human peripheral blood lymphocytes in vitro.

The project research will be of undoubted scientific and scientific-practical value owing to urgency of the problem of tritium and tritium oxide biological effect assessment, as well as the problem of safety for personnel handling tritium and prediction of delayed tritium effects on the human organism.

Possible role of foreign collaborators

Earlier there were no direct contacts with foreign partners due to specificity of the works and the Institute status.

The oral content support the project studies was expressed by Prof. A.M. Kellerer, GSF, Institut fur Strahlenbiologie, Neuherberg, D-85758 Oberschleissheim, Deutschland.

VNIIEF is interested in collaboration at the project realization with U.S. Lawrence Livermore National Laboratory, with Dr.R.A.Failor, Ph.D., Environmental Monitoring Section Leader.

The basic content on support of the research planned under the project on the side of U.S. Nuclear Centers was received from Dr.S.Younger.


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