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Versatile Medical Laser Apparatus

#B-819


Designing and Making of Development Type of Universal Laser System for Experimental Medicine Application

Tech Area / Field

  • INS-OTH/Other/Instrumentation
  • MED-DID/Diagnostics & Devices/Medicine
  • PHY-OPL/Optics and Lasers/Physics

Status
3 Approved without Funding

Registration date
22.10.2001

Leading Institute
Sagitta, Unitary Enterprise, Belarus, Minsk

Collaborators

  • Linline, Germany, Berlin

Project summary

Purpose of the Project.

The purpose of the project is to create an experimental sample of universal surgical laser apparatus for experimental medicine.

State of Affairs in the Research Sphere.

Experimental laser medicine comprises elaboration of methods of treatment of different diseases by means of finding optimal modes of laser emission’s effect on patient’s tissues. Experiments demand either several narrow-specialized laser apparatus or one universal (polyfunctional) apparatus. The “universality” of the apparatus supposes the possibility to change the wave length, energy (power) of emission, pulse duration, pulse repetition frequency [1].

The most “universal” of the laser apparatus known at present is the device for cosmetology “Versapulse” produced by Coherent [2]. It is equipped with four lasers with wavelengths of 532 nm, 750 nm, 1064 nm. The emitters with wavelengths of 532 and 1064 nm produce pulses with duration of 4-5 ns and 2-10 ms. The range of device characteristics is sufficient to perform several cosmetic operations, but the lack of a laser with the wavelength of ~ 2.94 mm, which corresponds to the maximum of absorption by water, together with small number of variants of temporal modes of emission limits the application of the mentioned apparatus in experimental medicine.

Influence of the Proposed Project on the Progress in this Sphere.

It is planned to create an experimental sample of the apparatus that will give the possibility to change spectral, energetic and temporal characteristics of emission in wider limits in comparison with the mentioned analogue. It is planned to equip the apparatus with five lasers of 4 wavelengths. Pulse duration will vary from nanoseconds to milliseconds. This will allow to optimise the degree of thermal effect on biological tissues by changing the ratio of average and pulse power of emission. This way gives possibility to cause both thermal and non- thermal effect [3]. With such apparatus the scientists will be able to develop new, more efficient methods of treatment, and also to optimise the existing methods of treatment of varicose veins [4], pigmented tumours [5], laser depilation [5] etc. The price of the apparatus (on the condition of manufacturing in the Republic of Belarus) is planned to be approximately of 60,000 $, which is less than the price of existing polyfunctional apparatus («Versapulse – 200,000 $) and is similar to the price of narrow-specialized apparatus. Low price together with advanced functional possibilities of the apparatus will make possible a wider distribution of medical laser equipment, especially in developing countries (Asia, Africa). The experimental sample of the apparatus can be used as a prototype for serial production equipment (both polyfunctional and narrow-specialized) using new and improved old methods.

Competence of the Participants of the Project.

The project is intended to be carried out by the participants of one organization – unitary enterprise “Sagitta”. Some participants of the project (their share in labour expenditure amounts to 55%) have the experience of design, manufacture and exploitation of military laser equipment (laser rangefinders, systems of location, detection and pursuit, target detection systems). Together with medical specialists and other specialists included in the staff of the project, they lately have participated in the creation of laser equipment for medical purposes. In collaboration with the specialists of Laser Centre of the Ministry of Health of the Republic of Belarus, there have been created new methods of treatment of pigmentary and vascular skin diseases [4,5], new methods of depilation [5] and tattoo removal [5]. The participants of the project have some technical solutions, results of several applied studies, patents and patent applications [4,5,6,7], and “know-how” related to the theme of the project. The staff includes 1 doctor of sciences and 3 candidates of sciences. All this contributes to the participants’ confidence in fulfilment of the project.

Expected Results and their Application.

Categories of work: applied researches and technology elaboration.

In the process of fulfilment of 4 project tasks, the following results will be obtained:

– Optical schemes will be designed; required characteristics of elements of lasers, design of five types of lasers will be defined; experimental samples will be manufactured and tested.


– Schematic circuits of laser functioning control unit (FCU) and q-switch control unit (QsCU) will be designed, a model of FCU and an experimental model of QsCU will be created. Designs of FCU and QsCU and software for apparatus control will be elaborated; experimental samples of FCU and QsCU will be manufactured and tested.
– Design of apparatus and design of removable laser modules will be elaborated; set of parts for chassis of apparatus and laser modules will be manufactured
– Assembly, adjustment and testing of laser apparatus will be carried out.

The result of the project will be an experimental sample of universal apparatus with a set of design documents, software, test logs of apparatus compliance with technical task requirements and a technical report.

Application of Obtained Results.

The experimental sample of the apparatus can be used for clinical research in the sphere of dermatology, cosmetology, angiology and odontology. It is planned to continue a joint research with specialists of the Ministries of Health of the Republic of Belarus and the Russian Federation, and to carry out demonstrations of the results of medical research to the Collaborator and other interested foreign specialists; also, to certify the apparatus. Upon clinical approbation of the apparatus the technical documents can be modified and used to manufacture an experimental lot.

The compliance of the Project with ISTC purposes is defined by the following:

– the “armoury” scientists and specialists participating in the project are granted a possibility to work in the sphere of peaceful activity – creation of new medical equipment;


– as the theme of the project is actual all over the world, the new results obtained upon fulfilment of the project, can be of international interest and can contribute to the integration of participants of the project in the international scientific – technical community;
– fulfilment of the project contributes to solution of international technical and humanitarian problems – creation of new medical equipment and increasing efficiency of treatment methods;
– fulfilment of the project creates a basis for elaboration of industrial samples of medical laser equipment and their manufacturing. This supports the transfer of the participants of the project to market economy, satisfying civil needs.

Volume of Work on the Project.

The project is planned to be carried out during 2 years. The work will be carried out by one head organization – unitary enterprise “Sagitta”. In the process of work the following tasks will be accomplished:

1. Design and manufacture of lasers.


2. Design and manufacture of electronic equipment of laser control.
3. Design and manufacture of parts of chassis of apparatus and lasers modules.
4. Assembly, adjustment and tests of the apparatus.

Role of Foreign Collaborator.

The foreign collaborator of this project is Jose Lopez Llurda, manager of the firm “Ingenieria del Laser Medico”, Barcelona, Spain. A preliminary agreement has been reached with him about the following forms of collaboration:

– information exchange during the work;


– carrying out joint tests and evaluation of results of design and manufacture of apparatus;
– carrying out a joint work seminar;
– participation in technical inspection of project activity by ISTC representatives;
– commentaries for the final technical report for ISTC;
– contribution to certification of the apparatus upon completion of the tests.

Technical Approach and Methodology.

The apparatus will include five plug-in solid-state lasers and a movable module with control and cooling units. It will be designed in accordance with international safety requirements for laser devices and electrical medical devices (IEC 825-1-93 and IEC 601-1-88). The following approach has been selected in order to make the apparatus meet the requirements of experimental medicine:

Regarding Task 1. The basic set of lasers will provide generation of emission with wavelengths of 0.53 mm, ~ 0.7 mm, 1.06 or 1.32 mm and 2.94 mm. This will give the possibility of causing effect on main biological agents – melanin, haemoglobin, and water contained in the tissues. The apparatus will have three temporal modes of generation – free running, q-switched single-pulse mode and multi-pulse mode. The latter mode is new for this class of apparatus, and its application for treatment is “know-how” of the participants of the project. It is planned to unify design and technology of main nodes of the emitters. During previous experiments the participants of the project have achieved results similar to those of analogous apparatus. With established requirements for emission characteristics it is planned to pay main attention to optimisation of optical schemes of the lasers, selection of types of laser rods and pumping system elements and optimisation of q-switch design in order to increase energetic efficiency and stability of characteristics.

Regarding Task 2. While designing electronic modules it is planned to guarantee the possibility of varying energy and power of pumping, pulse repetition frequency, simmer current, number of pulses in pulse train, compliance with international electrical safety and electromagnetic compatibility standards. By means of the system of sensors it will be possible to control the apparatus state and emission characteristics while working with patients. A built-in computer will make it possible to select between working mode. It is planned to create software package that will make it possible to work with the apparatus for both engineers-designers and medical staff.

Regarding Task 3. The lasers will have the form of compact modules that can be brought directly to the treated area of patient’s body. Besides, these devices must be resistible to external mechanical charges, i.e. they must not change their output parameters in conditions of vibration, blows, etc. In order to make the work with lasers comfortable, systems of their weight compensation will be elaborated. To make possible the use of lasers in endoscopic surgery it is planned to design the modules so that they could also work with fiber optic systems of emission delivery. The use of such modules requires high security of their hermetic properties and electric isolation, which will be carried out using “know-how” of the participants of the project and their experience in lasers for special application.

Regarding Task 4. The test programme of the apparatus will include control of emission characteristics in all programmed working modes, control of long time stability, control of compliance with international electrical safety and electromagnetic compatibility standards.

1. “Angewandte Laser Medizin”. Herauesgegeben von Hans-Peter Berlien und Gerhard Muller. Laser und Medizin-Technologie, Berlin, 1989.


2. Lasers in Medicine. Catalogue – directory of CIS and Baltic Countries. Moscow, 1998
3. See, for example, articles of V.V.Khomchenko and I.G.Liandres in: “Current Problems of Clinical Medicine”, Minsk, 1999, p. 72-74, p. 74-77, p.81-82, p. 147-148.
4. Decision of the grant of RF patent for invention application №2000123241/14(024945) of 10.11.2000.
5. Decision of the grant of RF patent for invention application №2000123232/14(024946) of 14.12.2000.
6. RF Patent №2096052.
7. RF Patent № 2101815, RF Patent № 2097887.


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