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Antioxidant Defense System in Blood Cells

#G-1089


Antioxidant Defense System Status as Blood Markers of Atopic Bronchial Asthma and the Influence of the Emerging Therapy

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology

Status
3 Approved without Funding

Registration date
21.10.2003

Leading Institute
Tbilisi State University / Institute of Physics (Ge), Georgia, Tbilisi

Collaborators

  • Lawrence Berkeley National Laboratory, USA, CA, Berkeley

Project summary

The environmental contamination has become a serious health concern. Different ecologically inauspicious factors permanently present in atmosphere, soil and water have the direct and indirect toxic and irritating impact on human systems and organs. The manifestation of bronchial asthma (BA) after acute and chronicle poisoning has exaggerated.

The hypothesis of this project is that health hazardous xenobiotics can be metabolized inside a cell generating of reactive oxygen species (ROS). An imbalance production of ROS plays a role in the pathogenesis of a number of human diseases, including allergy. When free radicals scavenging antioxidant systems are overwhelmed, inflammation, hypersensitivity, and autoimmune conditions may take place. As a first step, we propose to provide a fundamental understanding of abnormal immunity and oxidative imbalance.

This hypothesis will be tested by conducting experiments specifically designed to elucidate the relationships that exist between the free radical cellular damage produced by ROS in mononuclear blood cells of patients suffering from atopic bronchial asthma and the antioxidant defense system. The same relationship will be estimated during the therapy of bronchial asthma. The experimental technique will include the modern biochemical approaches and instrumentation, together with the unique analytical techniques developed at the Institute of Physics in the Republic of Georgia. Our proposed work will complement the research projects currently conducted by our U.S. collaborators at the Lawrence Berkeley National Laboratory.

Results from this project will allow one to realistically assess and elucidate the importance of antioxidant systems in the therapy of bronchial asthma, and the elaborated correlation may be used as hallmarks of the effective therapy.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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