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General Adaptation Syndrome

#G-1026


Neurohumoral Mechanism of General Adaptation Syndrome in Critical Condition

Tech Area / Field

  • BIO-CHM/Biochemistry/Biotechnology
  • INF-SIG/Sensors and Signal Processing/Information and Communications
  • MED-OTH/Other/Medicine

Status
3 Approved without Funding

Registration date
19.05.2003

Leading Institute
Highest Medical School AIETI, Georgia, Tbilisi

Collaborators

  • Rockefeller University, USA, New York

Project summary

Reaction to the stress or in other words General adaptation Syndrome is one of the most ancient and universal mechanisms of the human organism, which undertakes responsibility to maintain balance and adjust to permanently changing environment. Though it is not prepared to the flow of powerful stresses, so characteristic for our time and permanently affecting our organisms. Therefore we found reasonable to study and develop new aspects of protection mechanisms, to prevent death and heavy results of crisis - traumatic situations.

Adrenal system is a responsible "manager" for protection of life in extreme conditions. Recently in this context appeared data about major role of pineal gland. On the basis of above mentioned, at the first stage of our work we plan to study functions of adrenal and pineal glands in the initial phase (first minutes and hours) after the impact of a powerful stress factor (heavy trauma and damage of any etiology). Contingent for studying - patients in dramatically developing critical condition, with acute circulatory, respiratory, cardiorespiratory failure, clinical death, treated in PICU.

We shall regard functions of adrenal and pineal glands by the level of neurotransmitters and hormones of both glands (in the serum, urine and plasma). Obtained results will be compared with clinical characteristics and the outcome. On the basis of these materials we shall determine the algorithm, which will point, which stress response has protective character and which one - damaging, i. e. which threshold values of neurotransmitters are compensatory and which ones - pathological.

At the second stage, on the basis of obtained results, we plan at first experimentally and afterwards through clinical material, in the acute phase of a heavy stress, include in the treatment preparations of adrenocorrective action (lithium salts, adrenoblockers/adrenomymetics, melatonin), determine their optimal doses, with the purpose of preventing shock condition and for prevention of posttraumatic stress disorders. Create management algorithm for the initial phase of a heavy stress.

At the final stage of the project, with assistance of foreign collaborators and pharmacological firms, set the plan and create combined (lithium salts, adrenoblockers and melatonin) preparations for wide application. Combination of the ingredients will allow decreasing the doses under the toxic level. This preparation will be used in the acute period, in the conditions of any disasters (earthquakes, terrorist actions, military actions, heavy emotional stress etc.), in order to maintain stress reaction within the scopes of life protective mechanism, for decreasing of stress shock complications and prevention of posttraumatic stress disorders.

Project will be implemented on the basis of the highest medical school AIETI, in M. Iashvili Paediatric Clinical Hospital. Scientific-technical personnel of the Project include a group of multi - profile scientists: biochemists, specialists of critical medicine, endocrinologists, psychiatrists, pediatricians, pharmacologists, pathologists, programmers and instrumentation specialists. Some of them in the past were engaged in military developments.

Project implementation will allow Georgian scientists, including those, who have taken part in developing of secret themes, to contribute to fundamental aspects of neuroendocrinology and develop modern aspects of stress complications prevention.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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