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Phytoactive Polymers


Phytoactive Polymers – the New Preparations for Plant Growing

Tech Area / Field

  • CHE-POL/Polymer Chemistry/Chemistry
  • AGR-OTH/Other/Agriculture

3 Approved without Funding

Registration date

Leading Institute
INEOS (Organo-Element Compounds), Russia, Moscow


  • University of Crete, Greece, Heraklione

Project summary

The project is directed on development of new generation of economically promising preparations, corresponding polymeric derivatives of plant growth and development regulators, and contributing increasing of agriculture crops, in particular, under the conditions of outer stress effects. Realization of this work is especially important from the point of view of necessity in development of technologically available ways for supplying needed amounts of food in the conditions of abrupt population growth.

Recently, the serious attention is paid to plant growth regulators polymeric derivatives (phytoactive polymers) due to their several important advantages in regard to simple low-molecular preparations. Among these advantages are:

  • Hight efficiency at low preparation consumption,
  • Prolonged activity (controlled release),
  • Wide range of stimulating dozes and concentrations,
  • Reduced possibility of phytotoxicity appearance,
  • Safety to human and animal,
  • Ability for application in any agricultural technologies.

Investigations of phytoactive polymers which were carried out during last several years showed their high efficiency for different types of agricultural plants. Obtained results are presented in several reviews, published by project participants and project collaborator [1-5].

At the same time, the wide application of phytoactive polymers is limited by technological complications of their synthesis, poor solubility in water at high, economically preferable abundance of introduced regulator, insufficient level of controlled release activity.

All mentioned impediments also refer to polymer derivatives of one of the major groups of plant growth regulators – auxins, stimulators of root and callus formation, which are aryl- and aryloxy- carboxylic acids are some of their derivatives, which can be effectively used in several agricultural technologies and which are the objects of present project.

Thus, the new approaches to construction of phytoactive polymers are needed which will make possible to put the solution of existing problems in this area on the technological level.

During the project fulfillment several approaches to synthesis of immobilized forms of auxins with controlled release action will be developed based on synthesis of polymeric derivatives of carboxylic acids of auxin group and this will allow introduction of greater amounts of regulator residues in polymer with preservation of the whole system solubility in water. It will lead to preparation of practically valuable products, which can be used in lower dozed with conservation needed amount of introduced regulator. Moreover, as it was shown in previously realized works, the increase of amount of side aromatic fragments in water-soluble polymers allow providing steric hindrance for active substance release during hydrolysis and thus providing its slower controlled release and reducing possibility of phytotoxicity or overdose effects.

For preparations of such polymers several approaches will be used which allow introduction of lyophilizing links of acrylic acid, N,N,N,N-dimethyldiallylammoniumchloride and salt forms of chitosan links in phytoactive polymer.

Synthesis of such polymers during the project fulfillment will be realized by copolymerization of allyl esters and amides of auxin group carboxylic acids with acrylic acid and N,N,N,N-dimethyldiallylammoniumchloride, preparation of polymeric amides of auxin group carboxylic acids with chitosan, and preparation of polymeric salts of N,N,N,N-dimethyldiallylammoniumchloride with chitosan.

In order to obtain water-soluble forms of regulators, additionally, method of introduction of low-molecular regulators in water-compatible nano-scaled aggregates of amphiphilic polymers which are original developments and investigation objects of project participants and project collaborator [6,7].

During the project fulfillment the following task blocks will be executed and solved:

  • optimization of synthesis and technological conditions for preparation of pointed above immobilized on the polymeric carriers auxin group carboxylic acids,
  • investigation of hydrolytical release of active substances in model conditions,
  • reveal of the interconnection between structure of obtained polymers and their biological activity in conditions of laboratory and vegetative experiments. Development of principal algorithm of interconnection “structure – release rate of active substance – phytoactivity” allowing further purposeful synthesis of phytoactive polymers.

Also, the project, undoubtedly, meets the aims of ISTC from the point of involving scientist in solving important and peaceful task.

The role of the project collaborators, well acquainted with presented area of science, will consist in joint discussion of the project plan and fulfillment and in joint realization of biological and toxicological investigations.


  1. Tsatsakis A.M., Shtilman M.I. Polymeric derivatives of plant growth regulators: Synthesis and properties. // Plant Growth Regulation.- 1993.- V.14.- N.1.- P.69-77
  2. Tsatsakis A.M., Shtilman M.I. Phytoactive polymers. New synthetic plant growth regulators.// Plant morphogenesis. / Eds.K.Angelakis and Tran Thah Van.- Plenum.Publ Co.: New-York - London.- 1993.- P.255-272.
  3. Shtilman M.I. Phytoactive polymers.// Polymer Science, Ser.B.- 1995.- V.37.- N.5-6.- P.251-259.
  4. Shtilman M.I., Tzatzarakis M.N., Voskanyan P.S., Tsakiris I.N., Tsakalof A.K., Tsatsakis A.M. Correlation between Plant Growth Regulator Release Rate and Bioactivity for the Series of Newly Synthesized Phytoactive Polymers.// J.of Plant Growth Regulation, 2006, V.25, N.3, P.211-218.
  5. Korshak Yu.V., Voskanyan P.S., Allan G.G. et al. // Russian Chemical Reviews, 2010 (in press).
  6. Kuskov A.N., Shtilman M.I., Goryachaya A.V., Tashmuhamedov R.I., Yaroslavov A.A., Torchilin V.P., Tsatsakis A.M., Rizos A.K. Polymeric Nanoscaled Drug Carriers Composed of Amphiphilic Poly-N-vinylpyrrolidones. // Journal of Non-Crystalline Solids, 2007, v.353 (10), p.3969-3975.
  7. Yamskov I.A., Kuskov A.N., K. K. Babievskii, B. B. Berezin, M. A. Krayukhina, N. A. Samoilova, V. E. Tikhonov, M. I. Shtil'man. Новые липосомальные формы противогрибковых антибиотиков, модифицированные амфифильными полимерами. // Прикладная биохимия и микробиология, 2008, N.6. С. 688-693.
  8. Kuskov A.N., Voskresenskaya A.A., Goryachaya A.V., Artyukhov A.A., Shtilman M.I.,Tsatsakis A.M. Preparation and characterization of amphiphilic poly-N-vinylpyrrolidone nanoparticles containing indomethacin..// J Mater Sci Mater Med. 2010 Feb 23.


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ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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