Development of the phage-probiotic complex for veterinary use
Tech Area / Field
- AGR-VTH/Vaccines and Theraupetics/Agriculture
3 Approved without Funding
Georgian Academy of Sciences / Institute of Bacteriophage, Microbiology and Virology, Georgia, Tbilisi
- University of Minnesota, USA, MN, St Paul\nInstitut National de la Recherche Argonomique/INRA, France, France, Nantes\nLawson Health Research Institute, Canada, ON, London\nUniversity of Ghent, Belgium, Ghent
Project summaryDespite improving hygiene and improved sanitary standards for food production, intestinal infections are emerging all over the world and in Georgia as well. Roughly 30% of food-borne diseases are due to bacteria. According to the data of the Georgian NCDC (2009-2010) the cases of intestinal diseases are especially frequent among children below 14 years and adult foreign visitors. The most commonly recognized food-borne infections in Georgia are those caused by the bacteria Salmonella, Shigella, and E. coli O157:H7. The intestinal infections in Georgian population are frequently causing morbidity and provoking many deleterious consequences. http://www.ncdc.ge/index.php?do=fullmod&mid=210.
Antibiotic resistance is one of the world most pressing public health problems. Often the standard antibiotic treatments of intestinal infections are inefficient. Hence it would be highly desirable to control these often food borne infections by all possible means.
There are several approached aimed at limiting use of antibiotics in animal farms, these are: competitive exclusions (CE), probiotics and bacteriophages
The objective of the project is:
Efficient control or elimination of bacterial food-borne intestinal infections in Georgia disseminated through food chain and/or water.
This goal will be realized using a dual approach: by applying a combination of the natural bacterial antagonists such as probiotic bacteria and bacteriophages.
The beneficial effects of this strategy will be validated in vitro and in vivo on animal test using the soil nematode Caenorhabditis elegans as a surrogate model.
In vitro tests will be performed using standard bacteriology and biochemistry methods.
In vivo tests approving efficacy of probiotics and bacteriophages will be done using Nematodes, in particular Caenorhabditis elegans, which presently are extensively applied to replace expensive animal trials.
The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.
ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.