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Chromosome Aberrations Caused by Antitumor Preparations

#A-301.2


DNA and Chromosome Alteration Caused by Newly Synthesized Potential Antitumor and Carcinogenic Compounds. Comparison with Radiation Effects

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-RAD/Radiobiology/Biotechnology
  • MED-OTH/Other/Medicine

Status
8 Project completed

Registration date
16.11.2000

Completion date
19.02.2008

Senior Project Manager
Melnikov V G

Leading Institute
Yerevan State University, Armenia, Yerevan

Collaborators

  • US Department of Health & Human Services / National Institute of Health / National Cancer Institute, USA, MD, Bethesda\nUniversity of Florence / Departament of Chemistry, Italy, Florence\nBoston University/Center for Advanced Biotechnology, USA, MA, Boston\nUS Department of Health & Human Services / National Institute of Health / Institute of Child Health and Human Development, USA, MD, Bethesda\nUniversity of Pennsylvania / Leidy Laboratory of Biology, USA, PA, Philadelphia\nGeorgia Institute of Technology / School of Biology, USA, GA, Atlanta\nUniversity of Illinois, USA, IL, Chicago\nDipartimento Farmaco-Chimico, Italy, Bari

Project summary

The present Work plan is a result of implementation of ISTC #A-301d (PDG) financed by the USA. The following corrections have been introduced in the Work plan in comparison with primary #А-301 Project:

1. The configuration of the Project has been optimized.

2. The Project will be fulfilled in one organization (Yerevan State University).

3. The ideology of chromosome investigations is changed and modern methods of investigation are introduced. These investigations will be carried out at the Department of Genetics and Cytology of Yerevan State University (YSU).

4. Laser spectroscopic investigations are considerably reduced and structural investigations are widened.

5. As a result of Project optimization, its estimate of cost was reduced from $500,000 to $308,000; The List of necessary equipment was revised and reduced. Not long ago, a computer and centrifuge mentioned in the primary Project were bought using other sources. There is no necessity to buy a microscope, because there is the Microscope IBAS “OPTON” at the Department of Biology of YSU. It was decided to carry out microcalorimetry and circular dichroism studies using equipment of YSU. It is planned to carry out some experiments in the laboratories of foreign collaborators. As a result, the cost of equipment is reduced from $50,000 to $23,700 in comparison with the primary version of the Project. Changes in the List of materials of the previous version of the Project reduce cost of materials from $50,000 to $10,500.

6. The Project personnel were optimized: the number of participants was shortened from 41 to 31 person. The scientific potential of team is reinforced due to inclusion of more qualified specialists in the Project. 10 doctors and 14 candidates of sciences participate in the Project. New Project participants – doctors of sciences – lead the groups of genetic investigations and porphyrin synthesis.

7. A Database for all the sections of the PDG Work plan is created as an Access-file. It gives a possibility to introduce and edit any information about the scientific centers, laboratories and scientists, as well as about the firms working in the area of biotechnology and drug production. The Database is an open system, which allows in the future developing and enriching its logical structure creating new links and relations between the units. During the implementation of the main project the Database will be systematically updated. It can be used in the future for the obtaining of statistical data on the effectiveness of application and on the orientation in using of existing antitumor drugs. The main attention was given to the information gathering about antitumor drugs and the firms working in the area of biotechnology and drugs industry. The information on more than 500 names of antitumor drugs is gathered. There is a List of 500 firms in the area of biotechnology and drugs industry. For 440 of these firms the information has been gathered. Some of these firms are considered as potential collaborators and partners of the Project. Taking into account the possibility of application of #А-301.2 Project, this information may be of essential significance in the search of potential consumers of Project results and their further commercialization. This work will require additional analysis of Proposal from the economical point of view, future evaluation of the market and development of Technology Implementation Plan (TIP). Finding of partners for joined investment projects may be considered as a final result of this work.

8. As a result of PDG implementation new foreign collaborators are included in the Project.

The goal of the present Project is the fundamental investigation of molecular mechanisms of biological activity of newly synthesized metal complexes which are potentially antitumor substances; the comparison of their action with already known antitumor substances, as well as the elaboration of new strategies on creation of more effective antitumor drugs. The mechanism of biological action of appointed substances would be also compared with the radiation effects at the DNA and chromosome levels.


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The International Science and Technology Center (ISTC) is an intergovernmental organization connecting scientists from Kazakhstan, Armenia, Tajikistan, Kyrgyzstan, and Georgia with their peers and research organizations in the EU, Japan, Republic of Korea, Norway and the United States.

 

ISTC facilitates international science projects and assists the global scientific and business community to source and engage with CIS and Georgian institutes that develop or possess an excellence of scientific know-how.

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