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Fetal-Maternal Status Influence on Allergic Sensitization

#G-764


Effects of Fetal-Maternal Allergic, Antioxidant and Cytokine Status on the Allergic Sensitization in Early Childhood

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-CHM/Biochemistry/Biotechnology
  • MED-OTH/Other/Medicine

Status
3 Approved without Funding

Registration date
03.07.2001

Leading Institute
Tbilisi State Medical University / Central Clinic / Center of Allergy and Immunology, Georgia, Tbilisi

Project summary

The main objectives of the suggested project imply: to reveal integral influence of allergic, antioxidant status and Th1/Th2 cytokine balance of mothers on the antioxidant and anti-inflammatory properties of collostrum and breast milk and allergic sensitization in early childhood.
The immune system of the newborn infant is influenced by genetically predisposition (3) and maternal immunity, both transplacentally (1) and the breast milk (17). The Th2-like immune responses related to atopic disease (15) are also involved in a successful pregnancy (19). Th2-skewed cellular immune responses to common environmental antigens are presented already in utero, suggesting the Th2 response as the primary response early in life (20).
The relationship between breast-feeding and infant allergy is poorly understood, and the results from different studies are controversial (21,22) that could be explained by differences in the composition of human milk. Breast milk also contains numerous components with anti-inflammatory and antioxidant effects. Antioxidant, such as -tocopherol, cystein and ascorbic acid and the presence of catalase and glutatione peroxidase, enzymes participating in the catabolism of hydrogen peroxide, contributes to the antioxidant properties of human milk (6,13). There is a significant reduction in the total antioxidant status in asthmatics, chronic obstructive pulmonary disease patients, smokers, as well in premature babies at risk of the development of asthma. The fact that free oxygen radicals have strongly inhibitory effect on the production of IFN- suggests that antioxidants in the diet may have an antiallergic effect. The continually decreasing intake of dietary oxidants that has been observed in developed counties over the past 30 years (14) may therefore have contributed to the rising allergy prevalence (23).
Thus the presented project suggests:
1. Revealing of allergic, antioxidant and cytokine profile interactions of atopic and nonatopic pregnant women and their husbands with consideration of allergic/antioxidant dietary peculiarities of rural and urban regions;
2. Revealing of allergic, antioxidant and cytokine profile interactions of collostrum and breast milk;
3. Detection and follow-up of the effects of fetal-maternal allergic, antioxidant and cytokine status on the allergic sensitization in early childhood.
The project will be realized at the laboratory of the Center of Allergy and Immunology of Tbilisi State Medical University Central Clinic.
The project will be referred category of applied sciences.
Final results of the carried out research work can be the following:
1. Identification of possible relationship between allergic, decreased antioxidant status and inflammatory cytokine profile with dietary factors and behavior habits of pregnant women from rural and urban area;
2. Establishment of the possible differences in allergic, antioxidant and anti-inflammatory properties of the human milk of atopic and nonatopic mothers from rural and urban area;
3. Establishment of the possible protective, anti-inflammatory and antioxidant properties of the colostrum and breast milk on the development of sensitization in early childhood;
4. Detection of the influence of antioxidant and allergic status of fathers on the development of atopy in early childhood;
5. Recommendations of adequate dietary with appropriate antioxidant and hypoallergenic products for the prevention of allergy in childhood.
Collaborators agree to:
· Cooperate in scientific research work provided by the project;
· Exchange information during the process of the project accomplishment;
· To give consultations (if necessary);
· Discuss the results and the obtained data at conferences;
· Visit and invite project participants if necessary.


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