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Alternative Technologies for Medical Radionuclide Production


Creation of Economic Alternative Technologies for Radionuclide Production for Medical Diagnostics and Therapy

Tech Area / Field

  • FIR-ISO/Isotopes/Fission Reactors
  • CHE-RAD/Photo and Radiation Chemistry/Chemistry

8 Project completed

Registration date

Completion date

Senior Project Manager
Novozhilov V V

Leading Institute
Khlopin Radium Institute, Russia, St Petersburg

Supporting institutes

  • St Petersburg State University, Russia, St Petersburg


  • Pennwood Chemicals Inc., USA, New York

Project summary

The production of radioisotopes for diagnostics and therapy inevitably faces the problems of economical character, protection of the environment and alleviation of labour-consuming process. The RPA “Khlopin Radium Institute” has developed rather efficient technologies for production of iodine-123 and technetium-99m, but the production of isotopes like 67Ga and 111In involves some difficulties concerned with considerable losses of the expensive starting enriched material. The present work is aimed at the development of scientific fundamentals and technologies for production of cyclotron and reactor radionuclides being used in nuclear diagnostics and radiation therapy (67Ga, 111In, 186,188Re) which are characterized by the following features:
– minimal labour-consuming procedure for separation of target product;
– high ecological safety of production process;
– high profitability of production process.

The project includes the following:

– development of physico-chemical basis for “dry” methods of radionuclide production;
– creation of new technologies for reprocessing of reactor and cyclotron targets based on the use of both traditional and alternative “dry” methods of separation;
– development of 188Re-generators.

The execution of the Project should permit to develop the regional production of medical radionuclides 67Ga, 111In, 186,188Re by means of new technologies.

The scientific results of the Project should be of interest in solving the fundamental problems of radiation materials technology and nuclear chemistry.

The realization of the Project would contribute to:

– participation of highly-skilled scientists and engineer engaged earlier in the development and production of weapons in the fundamental and applied radiochemical and nuclear-physical studies;
– conservation of scientific and technical potential of the RPA “ Khlopin Radium Institute” and St. Petersburg State University;
– strengthening the scientific, engineering, industrial and export potential of the RF (Primarily St.-Petersburg and the North-Western region).


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