Telecommunication System for Laser Tumor Screening
Telecommunication System of laser Analyzers for Screening of Malignant Tumors
Tech Area / Field
- INF-SOF/Software/Information and Communications
- MED-DID/Diagnostics & Devices/Medicine
3 Approved without Funding
NIIIT (Pulse Techniques), Russia, Moscow
- Ministry of Health / FDMB&EP, Russia, Moscow\nCancer Research Center, Russia, Moscow
- Ecole Polytechnique Federale de Lausanne / Laboratoire de Physique de Milieux Ionisés, France, Palaiseau\nGerman Cancer Research Center, Germany, Heidelberg
Project summaryBecause of a steady growth of malignant tumours in the world and forecasted data that only in Russia every third person will suffer from cancer by 2001, the problem of an early diagnosis of malignant tumours and introduction of efficient screening methods is one of the high-priority problems facing the world community.
The development of pathologic processes in a human body is accompanied by changes in a number of molecular parameters of biological fluids. Investigations of the optical properties of biopolymers, including blood plasma proteins, have demonstrated the effectiveness of a dynamic scattering method used for checking these parameters and its efficiency for the multi-parameter molecular analysis of the blood plasma protein solution performed to diagnose the presence or absence of malignant tumours.
At the Cancer Research Center of the Russian Academy of Medical Sciences (CRC RAMS) an active appraisal of the above method is under way with the use of a prototype of laser blood analyzer (LBA) which is a modern computer complex combining the preparation of a sample, observation of intensity fluctuations and determination of light scattering dynamic spectrum density, determination of the values of information indices, formation of database and determination of statistical reliability of each diagnostic investigation.
The parameters used for diagnosis possess a high correlation with pathological condition and a low value of mutual correlation. This permits to perform a diagnosis at early stages of illness, when traditional methods are not applicable, to monitor inpidually the medicinal therapy and radiotherapy, and to take measures preventing the development of the process of malignancy upon exposure to strong carcinogens.
At present, the common data array seems to be rather convincing to declare the diagnostic effect, but still not sufficient to transfer the laser blood analyzer from the class of research instruments to the class of facilities used for express diagnosis. The methodological, technical and programming solutions call for large-scale verification-diagnostic investigations. A long-term estimate of the cost of a single blood plasma analysis is 5 to 10$ and, thus, is a fine prerequisite for appearance of a self-developing network for population screening.
The purpose of the Project is to lay a foundation for screening and express diagnosis of malignant tumours with an open verification-diagnostic database. The openness means the incorporation of diagnostic centres, hospitals and polyclinics into the system of health institutions of any level after installation of measuring and receive-transmit modules and their connection to the telecommunication channel used for connection with the central server.
The pilot telecommunication system for screening of the malignant tumours will be oriented at the contingent of closed administrative-territorial formations of the Ministry of Atomic Energy of Russia (towns: Glazov, Lesnoi, Obninsk, Ozersk, Sarov, Seversk, Electrostal), clinic No. 6 of the FDMB&EP, and patients of the CRC RAMS where modern experimental and clinic-diagnostic facilities are available.
The laboratories of biochemical analysis are suggested for use as a basis for the pilot network of measuring stations of laser spectroscopic blood analysis. The developed principles and methods possess an unrealised potential and according to the main idea of the Project shall provide an increase in reliability of the diagnostic decisions taken as more information is accumulated.
The main tasks of the Project are as follows:
— substantiation and issue of medical and technical requirements on the development of problem-oriented verification and reference sections of the RIPT central server database;
— further improvement of the criteria and methods for estimation of diagnostic efficiency and support of verification-diagnostic measures;
— development of the problem-oriented database around the RIPT central server and its software. The database sections shall include a dynamic programming-diagnostic module, reference and verification sections, a standard multivariable statistical analysis module, and a service module to provide visualization, documentation, record-keeping, coding, monitoring and other functions including the contingent of persons who were exposed to radiation during the breakdown at the Chernobyl atomic power plant.
— manufacture of a series of measuring modules of laser blood analyzers, their installation at the measuring stations of biochemical laboratories, and their scheduled maintenance;
— development, introduction and operation of communication channels of the measuring modules of laser blood analyzers with the central problem-oriented server.
The entire complex of work is based on a long-standing research and development of telecommunication systems, systems used for picking off data from measuring devices, creation of database and programming of large hardware-software complexes at the RIPT, experimental and clinical research carried out at the CRC of the RAMS and investigation of biophysical effects caused by radiobiological action at the FDRB&EP.
The basis for scientific and technical approach and methodology of studies under the Project are the methodological, technical and programming decisions implemented in the methods of multi-parameter molecular analysis of the solution of blood plasma proteins. Use is to be made of the latest achievements in the field of systems engineering, informatics, computer engineering, communication and data transmission theory, methods of structural designing. It is anticipated that within the framework of the Project and in the course of large-scale verification-diagnostic investigations, the type of modern relational database will be selected and the database tables and their relationship will be worked out.
The distinctive feature of the Project is that it will directly transfer the experience gained in the military sphere to the sphere of high medical technologies. The expected results possess a commercial potential capable of providing a long-term economic foundation for the work of scientists and engineers previously engaged in the development of combat materiel and the study of damage effects of weapons on human beings.
The completion of the Project shall be related to certification of the laser blood analyzer and the telecommunication system as a whole as medicodiagnostic, the initiation of a serial production of laser blood analyzers and establishment of a telecommunication system for screening of malignant tumours at the international level.
Foreign partners are invited to participate in the work on the Project. The participation is not to be limited just to exchange of scientific and technical information, but may consist in the conduct of mutual or parallel research with the use of identical or similar diagnostic equipment. Actually, no mandatory financial contribution is expected; however, the cooperation would be more efficient if the level of interests allows the partners to find their own sources of financing in order to connect the laser analyzers to the pilot telecommunication network at any stage of research and development.
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