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a aDegliCyclodextrins in Waste Treatment


Preparation and Use of Cyclodextrin Derivatives for Treatment of Radiation Polluted Wastes

Tech Area / Field

  • BIO-REM/Bioremediation/Biotechnology
  • BIO-IND/Industrial Biotechnology/Biotechnology

8 Project completed

Registration date

Completion date

Senior Project Manager
Gremyakova T A

Leading Institute
Institute of Microbiology, Armenia, Abovian

Supporting institutes

  • State Microbial Depository Center, Armenia, Abovian


  • National Research Council of Spain / Institute for Chemistry Research, Spain, Sevillia\nUniversidad Complutense de Madrid, Spain, Madrid\nUniversita Degli Studi di Torino, Italy, Torino\nAalborg University, Denmark, Aalborg\nUniversity of Sevillia, Spain, Sevillia\nUniversität Karlsruhe / Polimer Institut, Germany, Karlsruhe\nJohann Wolfgang Goethe Universität / Institut für Angewandte Physic / Institut für Lebensmittelchemie, Germany, Frankfurt

Project summary

The Project concerns the study and use of cyclodextrins (CDs) and their derivatives for detoxification of industrial waste waters and air including those polluted with radionuclides.

Cyclodextrins are cyclic oligosaccharides produced mainly by certain species of aerobic sporeforming bacteria. They have remarkable ability to link and to form inclusions with many chemicals.

Institute of Microbiology of the National Academy of Sciences of Armenia (INMIA) and Republican Centre for Deposition of Microorganisms (RCDM) of the National Academy of Sciences and Ministry of Education and Science of Armenia have been for many years intensively working on the cyclodextrins biosynthesis. Many microbial cultures producing cyclodextrins have been isolated and well defined, biosynthetic pathways of their formation were studied and many derivatives were obtained by chemical synthesis.

The Institute was involved in R&D for military purposes in the Former SU and weapon scientists are engaged within the Project. Actually the Project represents the conversion of military R&D to civil needs.

Republican Centre for Deposition of Microorganisms participated in R&D of cyclodextrins and has a vast and well defined microbial culture collection and database including more than 2000 of well-defined extremophilic strains with many active producers of different types of cyclodextrins. It has qualified personnel and all facilities to solve the Project microbiological and biotechnological tasks.

On different stages of the Project some other institutions will be involved. The co-operation with the Armenian and Chernobyl Nuclear Power Stations to receive the samples of waste waters and some technical helps has to be emphasized.

The Project represents an integrated complex of microbiological, biotechnological, chemical and analytical study with application of modern technologies.

The main goal of microbiological investigations has to be the screening of microbial strains with specific activity to produce certain cyclodextrins, especially g-cyclodextrin and their new types. Based on the data received the database of microbial cultures for directed biosynthesis of certain types of cyclodextrins has to be created. Within the researches mentioned the production of cyclic oligosaccharides on the basis of fructose and other monosugars has to be studied.

Biotechnological researches aimed to evaluate the production of a-, b- and g-cyclodextrins by extremophilic forms of microorganisms in presence or absence of specific macrocyclic complexing agents with the high selectivity. Planning to prepare test samples with the development of process-engineering.

The modern chemical methods will be used to prepare and to carry out a comparative study of different derivatives of monomeric a-, b- and g-cyclodextrins as well as for synthesis and characterization of new insoluble derivatives of cyclodextrin polymers and co-polymers with suitable substances, including some polysaccharides and to use their inclusions as stationary phases for treatment of radiation wastes.

Methodological approaches for screening and development of the special filters on the basis of cyclodextrins for purification the air polluted with radionuclides will be developed. The filters will have not only the properties of absorption but also the ability of complexation on the molecular level.

The participating institutions are now actively engaged in the study of synthesis of different cyclodextrins and their derivatives and have almost all facilities and pilot-scale installations to carry out R&D mentioned, including process-engineering.

The results expected of the Project have the scientific, practical and economical significances, as the development of biotransformation of starch to large-ring-cyclodextrins and investigation of inclusion ability their monomeric and polymeric derivatives for treatment of radioactive wastes. The Project realization permits to facilitate the efficiency of detoxification processes of industrial and domestic wastes, including those with radionuclides contamination.

The realization of the Project providing former weapons scientists of INMIA and RCDM opportunities to redirect their talants to peaceful activities, in particularly for purification of industrial wastes, including those polluted with radionuclides.

The Project is open for international community: join investigations and production of perspective cyclodextrins and their derivatives, large-scale experiments and applications.

In the framework of Project Proposal the role of foreign collaborators is as follows:

- provide each other the new specific cyclodextrin derivatives for their investigation and references;
- shared use of test samples and certain equipment for characterization of inclusion ability of carriers obtained;
- information exchange in the course of project implementation;
- specialist exchange;
- joint pilot testing;
- participation in joint seminars.


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