Molecular Epidemiology and Molecular Biology of Enteric Yersinia

#3869

Molecular Epidemiology and Molecular Biology of Enteric Yersinia: Prevalence of a 37.5 kb DNA Segment Contributing to Pathogenicity of Yersinia Strains

Tech Area / Field

BIO-MIB/Microbiology/Biotechnology
BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology

Status
3 Approved without Funding

Registration date
15.05.2008

Leading Institute
Gamalei Institute of Epidemiology and Microbiology, Russia, Moscow

Collaborators

Canadian Food Inspection Agency, Canada, AB, Lethbridge

Project summary

Yersinia virulence factors are encoded by the genes having chromosomal or plasmid location. The plasmid designated as pVM82 is a conjugative plasmid of the enteric Yersinia that contributes to pathogenicity. It is responsible for massive outbreaks of pseudotuberculosis in the Russian Far East. The aim of the present study is to compare the 37.5 kb fragments, and determine if the plasmid contains genes responsible for virulence, in clinical isolates. We are planning to use various combinations of standard techniques in molecular biology, biochemistry and microbiology to solve this task.

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