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Rehabilitation Method under Radiation Disorders of Immune System

#K-150.2


Rehabilitation Method Program for Population Groups Suffering from Radiation Disorders of the Immune System

Tech Area / Field

  • BIO-RAD/Radiobiology/Biotechnology
  • MED-OTH/Other/Medicine

Status
3 Approved without Funding

Registration date
19.05.2000

Leading Institute
Kazakh Research Institute of Oncology and Radiology, Kazakstan, Almaty

Supporting institutes

  • Medical Production Cooperative "Sorbo", Kazakstan, Almaty\nThe Republican Government Enterprise on the basic of economic control rights “Research Institute for Biological Safety Problems” , Kazakstan, Gvardeiski

Collaborators

  • Centers for Disease Control and Prevention (CDC) / Centers for Disease Control and Prevention, USA, GA, Atlanta

Project summary

The objective of this Project is to study the structure of morbidity and immune system disorders for people living in regions with raised radiation background and to develop the appropriate rehabilitation methods.

According to multilateral survey (1990) T-system immunity analysis for Semipalatinsk Oblast habitants revealed the substantial qualitative and quantitative changes in composition of T-regulation subpopulations: T-helpers were lower than 400 cells per 1 microlitre of blood; the index Tx/Tc was lower 1.0; and circulating in blood immune complexes raised above the normal content. Here the long-term application of immune depressants (ordinary prescripted medication for blood diseases) has a negative impact in sense of heavy disorders in metabolism, infectious diseases, and risk of malignant tumors as well. So one of the most promising trends is adaptive immune therapy. Hemotransfusion as a method of adaptive immune therapy, however, in essentially is a transplantation of allogen immune competent cells, which could be a cause of secondary syndrome appeared in recipient organism due to “transplantant versus host” reaction (Blokhin N.N., 1976). In this situation the most effective and least harmful rehabilitation method to be considered is an application of plasmapheresis (plasmasorption). It is well-known that application of plasmapheresis for a number of syndromes normalizes the ratio of T-lymphocyte subpopulations and corrects the “antigen-antibody” ratio lowering the immune reactive proteins level and increasing the “deblocking” of mononuclear system (Balabolkin M.I., 1983). One can expect that these attractive features of the method will provide rehabilitation effect for case of radiation exposure. The successful and less-risked solution of this problem to be seemed should be a preliminary development and improvement of the method on experimental animals in model experiments for the different radiation doses and length.

Implementation of these works with facilities of Kazakh Research Institute for agriculture will make it possible for the defense researchers to adapt for market economics and to apply their scientific and methodological experience in civil area.


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