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Viruses with Genome Variability

#0550


The Viruses with High Degree of Genome Variability with Serious Epidemic Danger.

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology
  • BIO-CHM/Biochemistry/Biotechnology

Status
3 Approved without Funding

Registration date
06.02.1996

Leading Institute
Ivanovsky Institute of Virology, Russia, Moscow

Supporting institutes

  • Scientific Research Institute of Epidemiology, Microbiology and Infectious Diseases, Kazakstan, Almaty\nBelarussian Research Institute for Epidemiology and Microbiology, Belarus, Minsk

Collaborators

  • Toshiba General Hospital, Japan, Tokyo\nCenters for Disease Control and Prevention (CDC) / National Center for Infectious Diseases, USA, GA, Atlanta\nJichi Medical School / Immunology Division, Japan, Tochigi\nUniversität Marburg / Klinikum der Philipps, Germany, Marburg

Project summary

The object of the project is to organize the monitoring over -emerging and over emerging virus circulation from Bun.yaviridae, Orthomyxoviridae and Flaviviridae families characterizing by high degree of genome variability and high epidemiologic danger, molecular-epidemiologic studies of the feature of virus strains isolated from nature and humans. The problems of the project are the following: the studies by means of the methods of molecular epidemiology the natural virus variants with segmented genome from serogroup of California encephalitis, Crimean hemorrhagic fever /and other little known members of Bun.yaviridae family as well as natural variants of influenza A viruses which can be the predecessors of new pandemic viruses. It will give a chance to observe the tendsnce of movement of genetic material in viral populations in nature, to analyse their variability and to reveal in time the emergence of natural virus reassortans with changed antigenic and biological features. The purpose of the project as well is to study heterogeneity of the population circulating in northern Eurasia of hepatitis С viruses, to reveal its genotypes depending on geographic, ethnic and other features.

The obtained results will give an opportunity to work out modern high-sensitive to different genotypes of viruses diagnostic test-systems /and prophylactic preparations with due regard for virus variability (the appearance of new reassortans of bunyaviruses, or influenza viruses with new antigenic and pathogenic features, or new genotypes of hepatitis С virus).

The methods of monitoring of viral infections with clinical research of the diseases, with isolation and identification of isolated viruses and methods of molecular epidemiology including polymerase chain reaction, the studies of primary structure of virus genome. It is supposed that the development of collaboration with the foreign laboratories specializing in mentioned problems, with some of which such collaboration exists already: on the problem of Bunyaviruses - with Colorado State University, Fort Collins, USA; Influenza viruses - with St. Jude Chiidrens Research Hospital, Memphis. USA, and Institute fur Uirologie, Marburg, Germany: Hepatitis С viruses - with Toshiba General Hospital, Tokyo, and Jichi Medical Scool, Toshigi, Japan.


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