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Genetic Polymorphism of HIV-1

#3826


Genetic Polymorphism of HIV-1 in the Former USSR Republics

Tech Area / Field

  • BIO-CGM/Cytology, Genetics and Molecular Biology/Biotechnology

Status
8 Project completed

Registration date
28.09.2007

Completion date
30.01.2012

Senior Project Manager
Melnikov V G

Leading Institute
Ivanovsky Institute of Virology, Russia, Moscow

Supporting institutes

  • Republic Center for Prevention and Avoidance of AIDS Infection, Kazakstan, Almaty\nRepublica Association "AIDS", Kyrgyzstan, Bishkek\nArmenian National AIDS Prevention Center, Armenia, Yerevan

Collaborators

  • University of Amsterdam / Academic Medical Center, The Netherlands, Amsterdam

Project summary

The HIV-infection epidemic has been rapidly spreading in Russia as well as other former Soviet Union republics. Most of these countries start the national HAART programs. The effectiveness of these programs will depend substantially on choosing the adequate means of disease control and surveillance. Of considerable importance in the right choice of such means are genetic properties of HIV-1 circulating in the regions.

Our study will focus on genetic persity of HIV-1 variants circulating in Armenia, Kazakhstan, and Kyrgyzstan. The main technical approaches to be applied include collecting samples of serum and blood cells from HIV-infected persons, serological assays, heteroduplex mobility assay, RNA and DNA sequencing, phylogenetic analysis. The molecular epidemiological studies will provide an insight into the prevalence of HIV-1 subtypes as well as frequency of transmission of HIV-1 strains bearing mutations associated with drug resistance. At present the conventional molecular monitoring of HIV-infection epidemic in Russia as well as the study of mutations associated with HIV-1 drug resistance is performed in the laboratory of T-lymphotropic viruses of Ivanovsky Institute of virology, Moscow. This program is supported and funded by the Russian Ministry of Health as a part of the Federal special program for HIV-infection prophylaxis.


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