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Sedative and Spasmolytic Drags


New Environmental Save and Economical Technology for Production of Sedative and Spasmolytic Drugs “Ethyl Ether of Alfa-Bromisovaleric Asid” and “Corvalolum”

Tech Area / Field

  • CHE-IND/Industrial Chemistry and Chemical Process Engineering/Chemistry
  • CHE-SYN/Basic and Synthetic Chemistry/Chemistry

3 Approved without Funding

Registration date

Leading Institute
Research Institute of New Chemical Technologies and Materials, Kazakstan, Almaty

Supporting institutes

  • The Republican Government Enterprise on the basic of economic control rights “Research Institute for Biological Safety Problems” , Kazakstan, Gvardeiski


  • Universita Ca'Foscari di Venezia, Italy, Venice

Project summary

The aim of the project: Carrying out the research and experience-construction works for elaboration a new, competitive and at the same time suitable for industrial introduction technology of obtaining the medicine “Ethyl ether of α-bromisovaleric acid” (EEBIA) and corvalolum and organization a small-scale production of these drugs.

Essence of the problem: The offered technology based on catalytic method of synthesis of EEBID from isobutylene, carbon monoxide, ethanol and bromine. The technology is highly-economic and highly- environmental safe. The production cost of the drugs (EEBIA, corvalolum) by the new technology is 3-4 times less than for the industrial technology.

Main problems which must be solved for achievement of the project aim:

  1. Finding optimum conditions of synthesis of EEBIA by the new technology;
  2. Working out of laboratory-technological regulations of obtaining of the drugs;
  3. Carrying out of the toxicological, pharmacological and pharmacopeic tests of drugs obtained by new technology;
  4. Working out of the Temporary pharmacopeic clause on the drugs, obtained by the new technology;
  5. Projecting and experience-construction works for arrangement a small-scale production of the drugs.

Importance of the project: Realization of the project will help to develop pharmaceutical industry of Republic of Kazakhstan. Now Kazakhstan because of weak development of pharmaceutical industry has to import about 95% of medicine. Participation in the project scientists formerly involved in weapons development will provide for them alternate job, connected with peaceful problems.

Role of Foreign Collaborators: Assistance in selection and ordering the necessary equipment and participation in joint research work for development the new technology for preparation of the drugs (EEEBIA, corvalolum).